… Nearly half of septic patients develop severe sepsis and septic shock. The mortality for …
being developed as therapeutic agents in sepsis as well. Diagnostic approach to severe sepsis …

… illness occurred during early “golden hours,” an effort was made to create a protocolized
approach for early identification and management of sepsis with the hope of reduced death [4]. …

… PA, Shelly M, Nasraway S, Tenaillon A, Bander J and Friedman G: IL-Ira administration
does not improve cardiac function in patients with severe sepsis. J Crit Care 14: 69-72, 1999. …

… The highly publicized CORTICUS (Corticosteroid Therapy of Septic Shock) study [17] might
… of volume substitution and insulin therapy in severe sepsis) trial may have influenced …

… In the most recent 'Sepsis-3' consensus definition, sepsis is … to infection, and the term severe
sepsis has been removed 3 . Of … of sepsis pathogenesis and potential novel approaches to …

… Accordingly therapeutic approaches to hyperglycemia in the management of severe sepsis
and septic shock have had much attention. Intensive insulin therapy became popular in the …

… patients with severe sepsis increased from 27% to 41% 26 . … being evaluated for sepsis
includes therapies that target both … 2015 approach to the diagnosis of sepsis and septic shock is …

… The clinical management of severe sepsis and septic shock has evolved dramatically
over the past decade and these new therapeutic approaches have been built on a deeper …

… therapeutic approaches, and the use of well-designed clinical trials (3). Roger Bone likened
the search for an effective therapy of sepsis to … with severe sepsis or septic shock and sepsis-…

… therapies for sepsis, it is also an important reminder that we need to change our approach to
therapy for … , this complexity demands that we reconsider our approach to therapy for sepsis. …