Characterization of pathogenic sepsis etiologies and patient profiles: a novel approach to triage and treatment

HH Dolin, TJ Papadimos, X Chen… - Microbiology …, 2019 - journals.sagepub.com
… pinpointed therapy improves sepsis patient outcomes provides some support for this
approach. It is true that in the initial effort to treat a patient at risk for severe sepsis or septic shock, …

Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis

RC Bone, RA Balk, FB Cerra, RP Dellinger, AM Fein… - Chest, 1992 - Elsevier
severe sepsis or sepsis with organ system dysfunction. Some have previously used the term
septic syndrome to describe this phase of the septic … The use of this approach is particularly …

Improved diagnostic approaches to infection/sepsis detection

BH Davis - Expert review of molecular diagnostics, 2005 - Taylor & Francis
… suffer severe infection or clinical symptoms similar to sepsis … of sepsis has evolved in the
past decades with new therapeutic options of improved antibiotics and more novel approaches (…

[HTML][HTML] Pulse high-volume haemofiltration for treatment of severe sepsis: effects on hemodynamics and survival

R Ratanarat, A Brendolan, P Piccinni, M Dan… - Critical Care, 2005 - Springer
… Based on the humoral theory of sepsis, a potential therapeutic approach involves high-volume
haemofiltration (HVHF), which has exhibited beneficial effects in severe sepsis, improving …

The hemodynamic derangements in sepsis: implications for treatment strategies

PE Marik, J Varon - Chest, 1998 - Elsevier
… use of novel therapeutic approaches, the mortality associated with the sepsis syndrome has
… patients with severe sepsis. This review evaluates the cardiovascular changes that occur in …

Strategies to improve drug development for sepsis

MP Fink, HS Warren - Nature reviews Drug discovery, 2014 - nature.com
… develop new therapies for sepsis have so far failed, and suggest some approaches that might
… Whereas the consensus definitions distinguish severe sepsis from sepsis by the presence …

Sepsis biomarkers

M Prucha, G Bellingan, R Zazula - Clinica chimica acta, 2015 - Elsevier
… improvements in support and therapy mean that the mortality is … The problem is high mortality
of severe sepsis, which is … How should we approach their interpretation then? The use of …

Immune therapy in sepsis: Are we ready to try again?

R Davies, K O'Dea, A Gordon - Journal of the Intensive Care …, 2018 - journals.sagepub.com
… future could be used as part of an integrated approach in guiding immune adjuvant therapy.
… To support a personalised immune-based therapeutic approach, laboratory tests that can …

Empiric antimicrobial therapy in severe sepsis and septic shock: optimizing pathogen clearance

SY Liang, A Kumar - Current infectious disease reports, 2015 - Springer
… shock, then empiric antimicrobial therapy must assume a position … antimicrobial therapy for
severe sepsis and septic shock … approach to antibiotic utilization in severe sepsis and septic

Diagnostic approach to sepsis—state of the art

FM Brunkhorst, K Reinhart - Sepsis and Organ Dysfunction: ... from Chaos …, 2002 - Springer
… and organ dysfunction, would allow early specific therapeutic … of therapy in patients with
severe sepsis and septic shock. … did not include patients with severe sepsis and, thus, organ …