… a new class of synthetic, potent, small-molecule ARE inducer, which we named AI-1, …
molecular target is Kelch-like ECHassociated protein 1 (Keap1). In contrast to known ARE inducers …

… Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that regulates Antioxidant
Response Element … Here we review the currently known small molecule ARE inducers and their …

… factor erythroid 2-related factor 2 (Nrf2) transcription factor is a major regulator of the cellular
antioxidant response… with promoters containing antioxidant response elements (AREs). ARE …

… Accordingly, Nrf2 activation by small molecule inducers may be a practical preventative …
other stress response elements were unchanged [including metal response element, interleukin-…

… and xenobiotics triggers the expression of a myriad of genes encoding antioxidant proteins,
… cis-acting elements in an array of Nrf2 target genes called antioxidant response elements (…

… Gene induction occurs through the antioxidant responsive element (ARE), a process that is
dependent on the Nuclear Factor-Erythroid 2p45-related factors, Nrf1 and Nrf2. Under basal …

… Induction of these enzymes is regulated at the transcriptional level and is … , the antioxidant
response element or ARE, found in the promoter of the enzyme's gene. The transcription factor …

… , consistent with the induction of antioxidant and phase II … ) appeared to be a stronger inducer
of NQO1 expression with a … all cells are affected by small molecule treatment in contrast to …

… antioxidant response element (ARE) reporter gene assay to systematically screen for oxidative
stress inducers … by a master transcription factor known as the NF-E2-related factor 2 (Nrf2)…

… antioxidants, is an important mechanism for protection against carcinogenesis. The transcription
factor Nrf2, which binds to the antioxidant response element (… for the induction of these …