The solubility behavior of drugs remains one of the most challenging aspects in formulation
development. Currently only 8% of the new molecules have both high solubility and
permeability. The drugs therapeutic efficacy depends upon the bioavailability and ultimately
upon the solubility. Salt formation, particle size reduction, etc. have commonly been used to
increase the dissolution rate of drugs, there are some practical limitations with these
techniques the desired bioavailability enhancement may not always be achieved. Solid …

The primary aim of this review was to improve the solubility and Bioavailability of BCS Class-
II drugs because of their low solubility and dissolution rate. Solubility is one of the imp
parameter to achieve desired concentration of drug in systemic circulation for
pharmacological response to be shown. Hence the class-II drugs require enhancement in
solubility and dissolution rate in there formulation development particularly in solid dosage
form such as in tablet and capsule. So because of this there are several methods and newer …