Solution-mediated phase transformation of aripiprazole: Negating the effect of crystalline forms on dissolution and oral pharmacokinetics

S Chung, J Kim, E Ban, J Yun, B Park, A Kim - Journal of Pharmaceutical …, 2020 - Elsevier
… , Washburn capillary rise method by Galet 31 … aripiprazole. In summary, rapid crystalline
form conversion of AA to MA and enhanced solubility by the excipients led to similar dissolution

pH-independent dissolution and enhanced oral bioavailability of aripiprazole-loaded solid self-microemulsifying drug delivery system

S Mahajan, D Singh, R Sharma, G Singh, N Bedi - AAPS PharmSciTech, 2021 - Springer
… C) as dissolution medium which is based on USP method for … aqueous solubility and oral
bioavailability of aripiprazole by … augment the solubility as well as bioavailability of aripiprazole. …

Enhanced dissolution and oral bioavailability of aripiprazole nanosuspensions prepared by nanoprecipitation/homogenization based on acid–base neutralization

Y Xu, X Liu, R Lian, S Zheng, Z Yin, Y Lu… - International Journal of …, 2012 - Elsevier
… In this study, aripiprazole (APZ), a weak alkaline drug with pH-dependent solubility, was …
Moreover, the precipitation process is not suitable for drugs that are poorly soluble in both …

[HTML][HTML] Aripiprazole-cyclodextrin binary systems for dissolution enhancement: effect of preparation technique, cyclodextrin type and molar ratio

SM Badr-Eldin, TA Ahmed, HR Ismail - Iranian journal of basic …, 2013 - ncbi.nlm.nih.gov
dissolution of aripiprazole utilizing the approach of complexation with cyclodextrins.
Phase-solubility … ratio, cyclodextrin type and preparation method on aripiprazole dissolution

Formulation and Evaluation of Fast Dissolving Tablets of Aripiprazole

P Gangotia, S Nehate, H Jain… - Research Journal of …, 2019 - indianjournals.com
method to mask the bitter taste of drug and fast dissolving tablets were prepared by direct
compression method … β-CD concentration, and S0 is the solubility of Aripiprazole in water, in …

Hydration Mechanism and Its Effect on the Solubility of Aripiprazole

Z Zheng, X Huang, N Wang, T Wang, L Zhou… - Pharmaceutical …, 2024 - Springer
… In this work, the reasons for the insolubility of aripiprazole Form III in water and the special
mechanism of the hydration process of Form III to Form H1 in water were systematically …

Design and Evaluation of a Self-Emulsifying Drug Delivery System of Aripiprazole.

AR Ramya, P Sudheer… - Indian Journal of …, 2019 - search.ebscohost.com
… the solubility and the dissolution rate of aripiprazole by … The preliminary solubility screening
of aripiprazole was … 41-NF-36 dissolution method for aripiprazole tablets, wherein 900 ml of …

[HTML][HTML] Experimental solubility of aripiprazole in supercritical carbon dioxide and modeling

E Ansari, B Honarvar, SA Sajadian, ZA Aboosadi… - Scientific Reports, 2023 - nature.com
… , solubility, and permeability of poorly water-soluble drugs is one of the major research topics
12 . The dissolution … SC-CO 2 solubility, in contrast, anti-solvent procedures are suitable in …

Modeling of Hansen's solubility parameters of aripiprazole, ziprasidone, and their impurities: A nonparametric comparison of models for prediction of drug absorption …

D Obradović, F Andrić, M Zlatović… - Journal of …, 2018 - Wiley Online Library
… , it must dissolve before it can be absorbed. Highly water-soluble medications dissolve more
… For the rest of compounds, the values are obtained by a reliable fragmentation method.12 …

Process control and in vitro/in vivo evaluation of aripiprazole sustained-release microcrystals for intramuscular injection

Q Cai, L He, S Wang, W Chu, L Zhou, W Pan… - European Journal of …, 2018 - Elsevier
solubility, intrinsic dissolution rate (IDR), and dissolution in vitro Equilibrium solubility: 50 mg
aripiprazole monohydrate and aripiprazole … intrinsic dissolution rate (IDR) of the aripiprazole