Thermodynamic analysis and molecular dynamic simulation of solid–liquid equilibrium behavior of antipsychotic drug aripiprazole (Form III) in three binary solvent …

H Wang, X Zhang - Journal of Molecular Liquids, 2023 - Elsevier
… negative, indicating that the dissolution process of APZ Form III … method for the separation
and preparation of crystals with specific structures. For the crystallization process, the solubility

Tuning physicochemical properties of antipsychotic drug aripiprazole with multicomponent crystal strategy based on structure and property relationship

Y Zhao, B Sun, L Jia, Y Wang, M Wang… - Crystal Growth & …, 2020 - ACS Publications
… the USP II paddle method in an RC-6 dissolution test system. Accurately … solubility and
poor dissolution behavior of APZ drug (BDDCS-II drug), we examined the powder dissolution

[PDF][PDF] Drug release profile of aripiprazole mouth dissolving polymeric formulation

P Parida, SP Tripathy, SC Mishra, A Behera - 2012 - academia.edu
… of aripiprazole, a poorly water soluble drug by forming dispersion with mannitol as water
soluble … Tablets were prepared by direct compression and Wet Granulation method. In both …

Solubility of Aripiprazole in supercritical carbon dioxide: Experimental and modeling evaluations

E Ansari, B Honarvar, SA Sajadian, ZA Aboosadi… - 2023 - researchsquare.com
solubility, and permeability of poorly water-soluble drugs is one of the major research topics
12. The dissolution … sc-CO2 solubility, in contrast, anti-solvent procedures are suitable for the …

Specific and Sensitive RP-HPLC Method Development and Validation for the Determination of Aripiprazole: Application in Preformulation Screening of Nanoemulsion

SA Kumbhar, CR Kokare, B Shrivastava… - … : Recent Patents on …, 2020 - ingentaconnect.com
solubility and bioavailability of aripiprazole by formulating a nanoemulsion. Due to course of
preformulation study, determination of solubility of aripiprazole … piprazole and dissolving in …

3D printed orodispersible films with Aripiprazole

W Jamróz, M Kurek, E Łyszczarz, J Szafraniec… - International journal of …, 2017 - Elsevier
soluble substance such as aripiprazole seems to be extra advantageous in terms of dissolution
… the impact of the extrusion process and aripiprazole presence on the film properties. X-…

Impact of jet pulverization and wet milling techniques on properties of aripiprazole long-acting injection and absorption mechanism research in vivo

X Guo, M Zhang, Y Guo, H Liu, B Yang, J Gou… - International Journal of …, 2022 - Elsevier
… that aripiprazole monohydrate has lower solubility in water (… 10.0 g of crude aripiprazole was
dissolved in 200 mL of ethanol … milling process also played a role in the faster dissolution of …

Aripiprazole and Dehydro-Aripiprazole Solid Solutions: Crystalline Combinations of Drug and Active Metabolite in Tailored Compositions

JT Trotta, TA Zeidan, PA Tilak, BM Foxman… - Crystal Growth & …, 2020 - ACS Publications
… (APZ) and its active metabolite, dehydro-aripiprazole (dAPZ), … Dissolution studies of the
hydrated system demonstrated the … in APZ and dAPZ solubilities result in solid solution …

Enhancement of in vivo efficacy and oral bioavailability of aripiprazole with solid lipid nanoparticles

Silki, VR Sinha - AAPS PharmSciTech, 2018 - Springer
Aripiprazole is a poorly soluble drug that, despite … dissolved in chloroform and subsequently
diluted with ethanol. The total drug content was estimated by UV spectrophotometric method

Morphological and crystalline transitions in monohydrous and anhydrous aripiprazole for a long-acting injectable suspension

X Tan, Y Zhong, L He, Y Zhang, G Jing, S Li, J Wang… - AAPS …, 2017 - Springer
… Many formulation and manufacturing processes can lead to … (APIs) such as solubility and
physical stability which influence … each tablet was exposed to the dissolution medium, 500 ml of …