Stabilizing effect of Soluplus on erlotinib metastable crystal form in microparticles and amorphous solid dispersions
S Jia, S Ning, Y Leng, Q Jing, Z Xu, F Ren - Polymers, 2022 - mdpi.com
… In this study, erlotinib microparticles (ERL MPs) and erlotinib solid dispersions (ERL SDs) …
Fourier transform infrared spectroscopy (FT-IR) showed that there was a hydrogen bond …
Fourier transform infrared spectroscopy (FT-IR) showed that there was a hydrogen bond …
Development of Erasin: a chromone-based STAT3 inhibitor which induces apoptosis in Erlotinib-resistant lung cancer cells
… with increasing concentrations of Erlotinib over an extended period of time, we produced
HCC-827-derived cells which had acquired over 400-fold reduced sensitivity to Erlotinib (EC 50 …
HCC-827-derived cells which had acquired over 400-fold reduced sensitivity to Erlotinib (EC 50 …
Evaluation of the interaction of novel tyrosine kinase inhibitor apatinib mesylate with bovine serum albumin using spectroscopies and theoretical calculation …
SB Kou, ZY Lin, BL Wang, JH Shi… - Journal of Biomolecular …, 2021 - Taylor & Francis
… A spectroscopic study on the interaction between the anticancer drug erlotinib and human
serum albumin. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 78(1-4), 405–…
serum albumin. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 78(1-4), 405–…
Co-encapsulated nanoparticles of Erlotinib and Quercetin for targeting lung cancer through nuclear EGFR and PI3K/AKT inhibition
… Erlotinib (Ertb), is an FDA approved drug for treating lung cancer as a monotherapy and/or
in combination therapy with gemcitabine. However, clinical studies showed that long term use …
in combination therapy with gemcitabine. However, clinical studies showed that long term use …
Sequential delivery of erlotinib and doxorubicin for enhanced triple negative Breast cancer treatment using polymeric nanoparticle
… Recent studies of signaling networks point out that an order of drugs to be administrated
to … of recalcitrant metastatic and drug-resistant cell types. In this study, a development of a …
to … of recalcitrant metastatic and drug-resistant cell types. In this study, a development of a …
Influence of surface modification and the pH on the release mechanisms and kinetics of erlotinib from antibody-functionalized chitosan nanoparticles
AR Srinivasan, SA Shoyele - Industrial & Engineering Chemistry …, 2014 - ACS Publications
… drug from these nanoparticles. The effects of surface modification by mAb on the release of
erlotinib … Fickian diffusion was elucidated to be the main mechanism of release of erlotinib …
erlotinib … Fickian diffusion was elucidated to be the main mechanism of release of erlotinib …
Click ferrocenyl-erlotinib conjugates active against erlotinib-resistant non-small cell lung cancer cells in vitro
P Biegański, M Godel, C Riganti, DF Kawano… - Bioorganic …, 2022 - Elsevier
… erlotinib together with their anticancer activity studies against erlotinib-sensitive A549 and
H1395 as well as erlotinib… Studies showed that extend of anticancer activity is mainly related to …
H1395 as well as erlotinib… Studies showed that extend of anticancer activity is mainly related to …
In silico evaluation of the resistance of the T790M variant of epidermal growth factor receptor kinase to cancer drug Erlotinib
… For this study, EGFR Kinase–Erlotinib complex conformations were generated through the
MD trajectories at equal intervals. Through these extensive free energy calculations, we found …
MD trajectories at equal intervals. Through these extensive free energy calculations, we found …
Simultaneous determination of erlotinib and its isomeric major metabolites in human plasma using isocratic liquid chromatography–tandem mass spectrometry and its …
T Ishida, T Naito, J Kawakami - Biomedical Chromatography, 2015 - Wiley Online Library
… This study developed a method for the simultaneous determination of erlotinib and its … The
m/z values of the precursor and product ions for the analytes were as follows: erlotinib, 394.2/…
m/z values of the precursor and product ions for the analytes were as follows: erlotinib, 394.2/…
Aptamer-conjugated chitosan-anchored liposomal complexes for targeted delivery of erlotinib to EGFR-mutated lung cancer cells
F Li, H Mei, X Xie, H Zhang, J Liu, T Lv, H Nie, Y Gao… - The AAPS journal, 2017 - Springer
… -loaded liposomal complexes, all formulations were centrifuged to separate the insoluble
free drug. The precipitate was analyzed by UV/Vis spectroscopy at 352 nm. The entrapment …
free drug. The precipitate was analyzed by UV/Vis spectroscopy at 352 nm. The entrapment …