Effects of Erlotinib in EGFR Mutated Non-Small Cell Lung Cancers with Resistance to Gefitinib

DB Costa, KSH Nguyen, BC Cho, LV Sequist… - … cancer research, 2008 - AACR
… All of the EGFR mutated patients from that study were included in our analysis and we
report updated clinical data in their response to both gefitinib and erlotinib. The second study

Erlotinib in the treatment of advanced non-small cell lung cancer: an update for clinicians

Y Wang, G Schmid-Bindert… - Therapeutic advances in …, 2012 - journals.sagepub.com
… Comparison between studies showed that gefitinib and erlotinib produced similar response
… and erlotinib in ISEL and BR.21 studies. Thus, in many countries and regions, erlotinib has …

[HTML][HTML] First-line erlotinib versus gemcitabine/cisplatin in patients with advanced EGFR mutation-positive non-small-cell lung cancer: analyses from the phase III …

YL Wu, C Zhou, CK Liam, G Wu, X Liu, Z Zhong, S Lu… - Annals of oncology, 2015 - Elsevier
… Post-study crossover means it is challenging to determine the true OS benefit … study was
that specific combinations of post-study therapy were not documented, eg maintenance erlotinib

Approval summary for erlotinib for treatment of patients with locally advanced or metastatic non–small cell lung cancer after failure of at least one prior chemotherapy …

JR Johnson, M Cohen, R Sridhara, YF Chen… - … Cancer Research, 2005 - AACR
… -free survival, and tumor response rate. Exploratory analyses … be an important predictor of
the erlotinib survival effect. Rash (… in 6% of erlotinib-treated patients and each resulted in study

Antitumor activity of erlotinib (OSI-774, Tarceva) alone or in combination in human non-small cell lung cancer tumor xenograft models

B Higgins, K Kolinsky, M Smith, G Beck… - Anti-cancer …, 2004 - journals.lww.com
… In this study we investigated whether combining erlotinib with cisplatin or gemcitabine in
athymic nude mice bearing NSCLC xenograft models acts synergistically or antagonistically in …

Gefitinib and erlotinib in metastatic non-small cell lung cancer: a meta-analysis of toxicity and efficacy of randomized clinical trials

M Burotto, EE Manasanch, J Wilkerson, T Fojo - The oncologist, 2015 - academic.oup.com
… this study was to compare the efficacy and toxicity of erlotinib… control arms of the erlotinib
and gefitinib studies used in this … of erlotinib studies. This similarity excludes any concern that …

Risk of interstitial lung disease with gefitinib and erlotinib in advanced non-small cell lung cancer: a systematic review and meta-analysis of clinical trials

L Shi, J Tang, L Tong, Z Liu - Lung Cancer, 2014 - Elsevier
… non-small cell lung cancer (NSCLC). Based on the results of two multicenter phase II studies
[1… Our search yielded a total of 496 potentially relevant studies with gefitinib or erlotinib. The …

Response to gefitinib and erlotinib in Non-small cell lung cancer: a retrospective study

IF Emery, C Battelli, PL Auclair, K Carrier, DM Hayes - BMC cancer, 2009 - Springer
… We evaluated data from our lung cancer patients to compare the benefits derived from erlotinib
and … We subsequently analyzed tumor tissue from a subgroup of these patients for a pilot …

Randomized phase II study of gefitinib versus erlotinib in patients with advanced non-small cell lung cancer who failed previous chemotherapy

ST Kim, JE Uhm, J Lee, J Sun, I Sohn, SW Kim… - Lung Cancer, 2012 - Elsevier
… In summary, this study demonstrated that both gefitinib and erlotinib showed effective anti-tumor
Further study with inclusion of both gefitinib and erlotinib in a properly conducted and …

Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a …

R Rosell, E Carcereny, R Gervais… - The lancet …, 2012 - thelancet.com
… -cell lung cancer (NSCLC) with activating EGFR mutations. We aimed to assess the safety
and efficacy of erlotinib … the European Tarceva versus Chemotherapy (EURTAC) study, in …