Randomized phase II trial of onartuzumab in combination with erlotinib in patients with advanced non–small-cell lung cancer

DR Spigel, TJ Ervin, RA Ramlau, DB Daniel… - Journal of clinical …, 2013 - ascopubs.org
… resistance to erlotinib has been observed in an NSCLC wild-type cell line (… study in patients
with recurrent NSCLC evaluating onartuzumab plus erlotinib versus placebo plus erlotinib

… interaction of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, with the multitargeted antifolate pemetrexed in non-small-cell lung cancer cells

E Giovannetti, C Lemos, C Tekle, K Smid… - Molecular …, 2008 - ASPET
… Because the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib
-cell lung cancer (NSCLC), empirical combinations of these drugs are being tested. This study

Randomized phase II study of fulvestrant and erlotinib compared with erlotinib alone in patients with advanced or metastatic non-small cell lung cancer

EB Garon, JM Siegfried, LP Stabile, PA Young… - Lung Cancer, 2018 - Elsevier
… an increase in lung cancer mortality was observed … studies have also reported an increase
in lung cancer mortality from combined hormone use, and increased incidence of lung cancer

… phase III trial of erlotinib versus docetaxel as second-or third-line therapy in patients with advanced non–small-cell lung cancer: Docetaxel and Erlotinib Lung Cancer …

T Kawaguchi, M Ando, K Asami, Y Okano… - Journal of clinical …, 2014 - ascopubs.org
… 1:1 to erlotinib or docetaxel by the … erlotinib and docetaxel, respectively, based on data
from previous clinical trials. The present study was designed to assess the efficacy of erlotinib

[HTML][HTML] Maintenance erlotinib versus erlotinib at disease progression in patients with advanced non-small-cell lung cancer who have not progressed following …

S Cicènas, SL Geater, P Petrov, Y Hotko, G Hooper… - Lung Cancer, 2016 - Elsevier
… The phase III IUNO trial assessed the benefit of maintenance erlotinib versus erlotinib at
progression in advanced/metastatic non-small-cell lung cancer (NSCLC) that had not …

Adjuvant erlotinib versus placebo in patients with stage IB-IIIA non–small-cell lung cancer (RADIANT): A randomized, double-blind, phase III trial

K Kelly, NK Altorki, WEE Eberhardt… - Journal of Clinical …, 2015 - ascopubs.org
… non–small-cell lung cancer (NSCLC). We hypothesized that erlotinib would be efficacious in
… In conclusion, this study did not show a DFS benefit for erlotinib in patients with IHC- or FISH…

[HTML][HTML] The concentration of erlotinib in the cerebrospinal fluid of patients with brain metastasis from non‑small‑cell lung cancer

Y Deng, W Feng, J Wu, Z Chen… - Molecular and …, 2014 - build.spandidos-publications.com
studies determining the erlotinib concentration in these patients is limited. The purpose of this
study was to measure the concentration of erlotinib … ‑small‑cell lung carcinoma. Six patients …

The global TRUST study of erlotinib in advanced non-small-cell lung cancer (NSCLC)

H Groen, OG Arrieta, H Riska, K Horwood… - Journal of Clinical …, 2008 - ascopubs.org
Erlotinib-related rash was observed in 70% of pts: the majority (83… from the BR.21 study and
confirm that erlotinib is an effective and … biomarkers for erlotinib will be presented separately. …

A Prospective Evaluation of Circulating Tumor Cells and Cell-Free DNA in EGFR-Mutant Non–Small Cell Lung Cancer Patients Treated with Erlotinib on a Phase II …

M Yanagita, AJ Redig, CP Paweletz, SE Dahlberg… - … Cancer Research, 2016 - AACR
… The primary objective of this open-label, nonrandomized phase II study was to prospectively
… treated with erlotinib until disease progression. Exploratory endpoints of this study included …

… as predictors of survival benefit from erlotinib for patients with non–small-cell lung cancer in the National Cancer Institute of Canada Clinical Trials Group study BR. 21

GM Clark, DM Zborowski, P Santabárbara, K Ding… - Clinical lung cancer, 2006 - Elsevier
… with squamous cell histology. Male ever-smokers with … cell non–small-cell lung cancer
derived a significant survival benefit from erlotinib (HR, 0.66; P = 0.015) despite a very low tumor