Randomized phase II trial of onartuzumab in combination with erlotinib in patients with advanced non–small-cell lung cancer
DR Spigel, TJ Ervin, RA Ramlau, DB Daniel… - Journal of clinical …, 2013 - ascopubs.org
… resistance to erlotinib has been observed in an NSCLC wild-type cell line (… study in patients
with recurrent NSCLC evaluating onartuzumab plus erlotinib versus placebo plus erlotinib…
with recurrent NSCLC evaluating onartuzumab plus erlotinib versus placebo plus erlotinib…
… interaction of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, with the multitargeted antifolate pemetrexed in non-small-cell lung cancer cells
E Giovannetti, C Lemos, C Tekle, K Smid… - Molecular …, 2008 - ASPET
… Because the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib …
-cell lung cancer (NSCLC), empirical combinations of these drugs are being tested. This study …
-cell lung cancer (NSCLC), empirical combinations of these drugs are being tested. This study …
Randomized phase II study of fulvestrant and erlotinib compared with erlotinib alone in patients with advanced or metastatic non-small cell lung cancer
EB Garon, JM Siegfried, LP Stabile, PA Young… - Lung Cancer, 2018 - Elsevier
… an increase in lung cancer mortality was observed … studies have also reported an increase
in lung cancer mortality from combined hormone use, and increased incidence of lung cancer …
in lung cancer mortality from combined hormone use, and increased incidence of lung cancer …
… phase III trial of erlotinib versus docetaxel as second-or third-line therapy in patients with advanced non–small-cell lung cancer: Docetaxel and Erlotinib Lung Cancer …
T Kawaguchi, M Ando, K Asami, Y Okano… - Journal of clinical …, 2014 - ascopubs.org
… 1:1 to erlotinib or docetaxel by the … erlotinib and docetaxel, respectively, based on data
from previous clinical trials. The present study was designed to assess the efficacy of erlotinib …
from previous clinical trials. The present study was designed to assess the efficacy of erlotinib …
[HTML][HTML] Maintenance erlotinib versus erlotinib at disease progression in patients with advanced non-small-cell lung cancer who have not progressed following …
S Cicènas, SL Geater, P Petrov, Y Hotko, G Hooper… - Lung Cancer, 2016 - Elsevier
… The phase III IUNO trial assessed the benefit of maintenance erlotinib versus erlotinib at
progression in advanced/metastatic non-small-cell lung cancer (NSCLC) that had not …
progression in advanced/metastatic non-small-cell lung cancer (NSCLC) that had not …
Adjuvant erlotinib versus placebo in patients with stage IB-IIIA non–small-cell lung cancer (RADIANT): A randomized, double-blind, phase III trial
K Kelly, NK Altorki, WEE Eberhardt… - Journal of Clinical …, 2015 - ascopubs.org
… non–small-cell lung cancer (NSCLC). We hypothesized that erlotinib would be efficacious in
… In conclusion, this study did not show a DFS benefit for erlotinib in patients with IHC- or FISH…
… In conclusion, this study did not show a DFS benefit for erlotinib in patients with IHC- or FISH…
[HTML][HTML] The concentration of erlotinib in the cerebrospinal fluid of patients with brain metastasis from non‑small‑cell lung cancer
Y Deng, W Feng, J Wu, Z Chen… - Molecular and …, 2014 - build.spandidos-publications.com
… studies determining the erlotinib concentration in these patients is limited. The purpose of this
study was to measure the concentration of erlotinib … ‑small‑cell lung carcinoma. Six patients …
study was to measure the concentration of erlotinib … ‑small‑cell lung carcinoma. Six patients …
The global TRUST study of erlotinib in advanced non-small-cell lung cancer (NSCLC)
H Groen, OG Arrieta, H Riska, K Horwood… - Journal of Clinical …, 2008 - ascopubs.org
… Erlotinib-related rash was observed in 70% of pts: the majority (83… from the BR.21 study and
confirm that erlotinib is an effective and … biomarkers for erlotinib will be presented separately. …
confirm that erlotinib is an effective and … biomarkers for erlotinib will be presented separately. …
A Prospective Evaluation of Circulating Tumor Cells and Cell-Free DNA in EGFR-Mutant Non–Small Cell Lung Cancer Patients Treated with Erlotinib on a Phase II …
M Yanagita, AJ Redig, CP Paweletz, SE Dahlberg… - … Cancer Research, 2016 - AACR
… The primary objective of this open-label, nonrandomized phase II study was to prospectively
… treated with erlotinib until disease progression. Exploratory endpoints of this study included …
… treated with erlotinib until disease progression. Exploratory endpoints of this study included …
… as predictors of survival benefit from erlotinib for patients with non–small-cell lung cancer in the National Cancer Institute of Canada Clinical Trials Group study BR. 21
GM Clark, DM Zborowski, P Santabárbara, K Ding… - Clinical lung cancer, 2006 - Elsevier
… with squamous cell histology. Male ever-smokers with … cell non–small-cell lung cancer
derived a significant survival benefit from erlotinib (HR, 0.66; P = 0.015) despite a very low tumor …
derived a significant survival benefit from erlotinib (HR, 0.66; P = 0.015) despite a very low tumor …