… This review discusses target protein degradation from a structural perspective and
highlights the evolution of certain degraders based on the obtained structural insights. …

… modifications and protein–protein interactions. The field of targeted protein degradation is
an … Cells expressing the tagged target protein are then treated with compound to induce …

… target effects can hamper compound efficacy. Nucleic acid-based strategies that control protein
… the cell's own protein destruction machinery for selective degradation of essential drivers …

… in complete target protein degradation unless they have been extensively optimized. The …
efficacy window of any targeted protein degradation compound. As levels of any given …

… Targeted protein degradation as a therapeutic modality has … : optimization of first-generation
peptidic proteolysis-targeted … advantageous and may allow compounds with only moderate …

… Targeted protein degradation requires several … optimization. Overall, the approaches and
assays described in this section are expected to work both for bRo5 and eRo5 compounds alike…

… We will start by examining the targeted protein degradation process and the range of …
When developing degrader compounds, it is important to optimize additional properties, …

… Therefore, evaluating degrader activity in the cellular context that phenotypic assays will be
performed in is advised if different to the workhorse cell lines of the compound optimization. …

… Finally, ligand-induced protein degradation was shown with … of PCSK9 and compound 1
to enable the optimization of the … protein-templated in situ click chemistry as a kinetic target-…

… optimization [22]. Furthermore, as PROTACs are required to individually bind both the
target protein … to structure-informed lead optimization to identify a compound that can re-enhance …