Activation of ERK and Akt signaling in focal cerebral ischemia: modulation by TGF-α and involvement of NMDA receptor
B Friguls, V Petegnief, C Justicia, M Pallàs… - Neurobiology of …, 2002 - Elsevier
… We studied the activation of ERK MAP kinase and Akt 1 h after … TGF-α treatment did not
alter ischemia-induced Akt activation, in spite of the fact that signaling through EGFR activates …
alter ischemia-induced Akt activation, in spite of the fact that signaling through EGFR activates …
[HTML][HTML] Rho/ROCK and MEK/ERK activation by transforming growth factor-α induces articular cartilage degradation
CTG Appleton, SE Usmani, JS Mort, F Beier - Laboratory investigation, 2010 - Elsevier
… is upregulated by OA chondrocytes, our findings indicate that MEK/ERK activation by TGFα
reduces anabolic activity and thereby the capacity to replace damaged and eroded articular …
reduces anabolic activity and thereby the capacity to replace damaged and eroded articular …
MEK-ERK pathway modulation ameliorates pulmonary fibrosis associated with epidermal growth factor receptor activation
SK Madala, S Schmidt, C Davidson… - American journal of …, 2012 - atsjournals.org
… The purpose of this study was to determine if ERK1/2 is activated during the progression
of lung fibrosis in the TGF-α model and identify the cellular distribution. A second goal was to …
of lung fibrosis in the TGF-α model and identify the cellular distribution. A second goal was to …
… C virus core protein activates the MAPK/ERK cascade synergistically with tumor promoter TPA, but not with epidermal growth factor or transforming growth factor α
J Hayashi, H Aoki, K Kajino, M Moriyama, Y Arakawa… - Hepatology, 2000 - Elsevier
… MAPK/ERK cascade was further activated by these mitogens (EGF and TGF-α) in cells
expressing HCV core protein (Fig. 3A). Interestingly, the activation of the MAPK/ERK cascade by …
expressing HCV core protein (Fig. 3A). Interestingly, the activation of the MAPK/ERK cascade by …
[HTML][HTML] Ectodomain shedding of TGF‐α and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades
H Fan, R Derynck - The EMBO journal, 1999 - embopress.org
… shedding, these mechanisms also mediate L‐selectin and TNF‐α cleavage. Thus, L‐… of
Erk MAP kinase or p38 MAP kinase signaling. Our results indicate that activation of Erk and p38 …
Erk MAP kinase or p38 MAP kinase signaling. Our results indicate that activation of Erk and p38 …
TGF-α increases human mesenchymal stem cell-secreted VEGF by MEK-and PI3-K-but not JNK-or ERK-dependent mechanisms
Y Wang, PR Crisostomo, M Wang… - American Journal …, 2008 - journals.physiology.org
… attenuated the additive effect of TGF-α and TNF-α on VEGF production of … TGF-α activates
a network of signaling cascades. Our study demonstrated that TGF-α (250 ng/ml) activated ERK…
a network of signaling cascades. Our study demonstrated that TGF-α (250 ng/ml) activated ERK…
TGF-β1 targets the GSK-3β/β-catenin pathway via ERK activation in the transition of human lung fibroblasts into myofibroblasts
F Caraci, E Gili, M Calafiore, M Failla, C La Rosa… - Pharmacological …, 2008 - Elsevier
… 1 h prior to TGF-β1. To investigate the role of ERK activation in the induction of α-SMA by
TGF-β1, we measured the expression of phosho-ERK1/2 (P-ERK1/2), the activated forms of …
TGF-β1, we measured the expression of phosho-ERK1/2 (P-ERK1/2), the activated forms of …
TGF‐β activates Erk MAP kinase signalling through direct phosphorylation of ShcA
MK Lee, C Pardoux, MC Hall, PS Lee… - The EMBO …, 2007 - embopress.org
… their activation is generally associated with tyrosine kinase signalling. However, TGF‐β
stimulation also activates Erk … We report that upon TGF‐β stimulation, the activated TGF‐β type I …
stimulation also activates Erk … We report that upon TGF‐β stimulation, the activated TGF‐β type I …
[HTML][HTML] Cross-talk between ERK and p38 MAPK mediates selective suppression of pro-inflammatory cytokines by transforming growth factor-β
YQ Xiao, K Malcolm, GS Worthen, S Gardai… - Journal of Biological …, 2002 - ASBMB
… Further investigation indicated that TGF-β activated ERK, which in turn up-regulated MAPK
… ERK and p38 MAPK is dysregulated by simultaneous TGF-β-stimulated ERK activation, …
… ERK and p38 MAPK is dysregulated by simultaneous TGF-β-stimulated ERK activation, …
[HTML][HTML] Non-Smad pathways in TGF-β signaling
YE Zhang - Cell research, 2009 - nature.com
… -β stimulation, which is comparable to the time course of Erk activation by mitogenic factors
… the delayed activation of Erk by TGF-β, it does not explain the rapid activation of Erk by TGF-β…
… the delayed activation of Erk by TGF-β, it does not explain the rapid activation of Erk by TGF-β…