… Therapeutic proteins have revolutionized the treatment of many diseases but low activity or
… , changing protein-associated carbohydrate to alter pharmacokinetic properties of proteins. …

… Recent or illustrative examples of N-linked and/or O-linked glycosylation impacting drug
pharmacology properties (including activity, pharmacokinetics, clearance, and immunogenicity) …

… , protein-based drugs routinely display suboptimal therapeutic efficacies due to their poor
physicochemical and pharmacological properties. … the therapeutic behavior of protein drugs. …

… in therapeutic protein production, the analytical methodologies employed for
glycosylation … being explored to use this property to improve therapeutic protein efficacy (glycoengineering). …

… factors, cytokines, and hormone-based therapeutic proteins whose properties have been
reported to be affected by glycosylation. A detailed description of these reported findings is …

… correlating the effect of O-glycosylation on protein properties based on the GlycoFi technology.
… to select engineered Pichia cell lines expressing the desired glycosylation properties. …

… OF GLYCOSYLATION Unlike the amino acid sequence of the therapeutic protein, glycosylation
… Glycoengineering: the effect of glycosylation on the properties of therapeutic proteins. J …

… achieve expected glycosylation in a recombinant protein. The … of the desired glycoform of a
therapeutic protein. Hence, these … to modulate the protein glycosylation is also recommended …

… This chapter gives a short presentation of the structure of glycans commonly found on
recombinant therapeutic proteins, and their role on the properties of the drug, in terms of stability, …

… Protein glycosylation is ubiquitous throughout biology. From bacteria to humans, this post …
of proteins with cells and changes the physiochemical properties of the proteins that carry them…