… They provide an evaluation of evolving therapeutics in sepsis and how they have built upon
… sepsis and the elicited immune response, it is not surprising that a single cure-all therapeutic …

… of polymicrobial sepsis and … in sepsis that can be a therapeutic target. In this respect,
experimental studies looking at the septic animal suggest that loss of lymphocytes during sepsis …

… evolution of sepsis therapy (Table 1) and identifies possible causes for why rational therapies
failed in human trials. In addition, this article examines potential future sepsis targets and …

… therapy for sepsis and these novel therapies may be tested in clinical situation in the future.
Herein, we review the therapeutic … on novel therapeutic targets for the treatment of sepsis. …

… While moderate pyroptosis in sepsis can … therapeutic targets underlying pyroptosis in
sepsis identified in recent decades, looking forward to the future direction of treatment for sepsis…

… pathogenesis and the target of clinical diagnosis of sepsis, with the goal of enhancing the
current understanding of sepsis. The present state of research on targeted therapeutic drugs is …

… after the induction of sepsis, which suggests a causal detrimental role of T cell exhaustion
and identifies the PD1–PDL1 axis as a potential therapeutic target in sepsis 42 . Monocyte …

… to sepsis pathophysiology. An important goal is to develop novel therapies that reverse
endothelial dysfunction in sepsis. … in sepsis and will highlight its untapped therapeutic potential. …

… into additional therapeutic agents directed against novel targets. Following a review of
recent advances in sepsis treatment, we briefly discuss a few of the new, promising therapeutic …

… caspasemediated apoptosis, represent an attractive therapeutic target for the septic patient.
In … apoptotic pathways in sepsis syndrome and propose several potential therapeutic targets. …