Cytotoxicity and cellular uptake of pyrimidine nucleosides for imaging herpes simplex type-1 thymidine kinase (HSV-1 TK) expression in mammalian cells
KW Morin, W Duan, L Xu, A Zhou, S Moharram… - Nuclear medicine and …, 2004 - Elsevier
In vivo transfer of the herpes simplex virus type-1 thymidine kinase (HSV-1 TK) gene, with
subsequent administration of antiviral drugs such as ganciclovir, has emerged as a promising …
subsequent administration of antiviral drugs such as ganciclovir, has emerged as a promising …
Validation of FLT uptake as a measure of thymidine kinase-1 activity in A549 carcinoma cells
JS Rasey, JR Grierson, LW Wiens… - Journal of Nuclear …, 2002 - Soc Nuclear Med
… accuracy with which FLT uptake predicted the activity of cytosolic thymidine kinase-1 (TK 1
)… the cellular uptake as a percentage of radioactivity in the same volume of medium. Uptake …
)… the cellular uptake as a percentage of radioactivity in the same volume of medium. Uptake …
Cytofluorometric assay for the determination of thymidine uptake and phosphorylation in living cells
M Hengstschläuger, E Wawra - Cytometry: The Journal of the …, 1993 - Wiley Online Library
… The cellular uptake of thymidine and its phosphorylation are coupled; consequently, the …
accumulation of phosphorylated thymidine analogues reflects the activity of thymidine kinase (25…
accumulation of phosphorylated thymidine analogues reflects the activity of thymidine kinase (25…
Intracellular uptake of thymidine and antiherpetic drugs for thymidine kinase-deficient mutants of herpes simplex virus type 1
PK Bae, JH Kim, HS Kim, IK Chung, SG Paik, CK Lee - Antiviral research, 2006 - Elsevier
… The cellular uptake of thymidine was highly dependent on the viral TK (vTK) activity. The TK
+ strain showed the highest level of intracellular thymidine uptake, … showed little uptake. The …
+ strain showed the highest level of intracellular thymidine uptake, … showed little uptake. The …
[PDF][PDF] Monitoring gene therapy with herpes simplex virus thymidine kinase in hepatoma cells: uptake of specific substrates
U Haberkorn, A Altmann, I Morr, KW Knopf… - Journal of Nuclear …, 1997 - Soc Nuclear Med
… pathway enzymes (eg, ofhost thymidine kinase activity during repair of cell damage).
Therefore, it is unlikely that a quantita tion with a standardized uptake value is useful! for the deter …
Therefore, it is unlikely that a quantita tion with a standardized uptake value is useful! for the deter …
… and Cellular Uptake of 2'-Substituted Analogues of (E)-5-(2-[125I]Iodovinyl)-2'-deoxyuridine in Tumor Cells Transduced with the Herpes Simplex Type-1 Thymidine …
KW Morin, ED Atrazheva, EE Knaus… - Journal of medicinal …, 1997 - ACS Publications
… cellular density (1 × 10 5 cells) in cell cultures of KBALB and KBALB-STK cells. The cellular
uptake of each compound (10−13) in both cell … Minimal uptake of all four compounds (10−13) …
uptake of each compound (10−13) in both cell … Minimal uptake of all four compounds (10−13) …
Thymidine uptake, thymidine incorporation, and thymidine kinase activity in marine bacterium isolates
WH Jeffrey, JH Paul - Applied and environmental microbiology, 1990 - Am Soc Microbiol
… Attempts to detect thymidine kinase genes in … thymidine kinase genes proved unsuccessful.
To determine if the inability to incorporate thymidine was due to the lack of thymidine kinase, …
To determine if the inability to incorporate thymidine was due to the lack of thymidine kinase, …
Thymidine kinase, DNA synthesis and cancer
S Kit - Molecular and cellular biochemistry, 1976 - Springer
… Especially striking is the increase of thymidine kinase activity, indicating that this enzyme …
The thymidine kinase isozymes of vertebrate cells have been characterized. Thymidine kinase F…
The thymidine kinase isozymes of vertebrate cells have been characterized. Thymidine kinase F…
Monitoring tumor cell proliferation by targeting DNA synthetic processes with thymidine and thymidine analogs
JL Schwartz, Y Tamura, R Jordan… - Journal of Nuclear …, 2003 - Soc Nuclear Med
… The initial step in TdR metabolism is phosphorylation by thymidine kinase-1 (TK 1 ). In …
To examine how some tumor-specific variations in cell biology influence PET tracer uptake, …
To examine how some tumor-specific variations in cell biology influence PET tracer uptake, …
The role of phosphorylation in the uptake of thymidine in mammalian cells
GS Schuster, JD Hare - In vitro, 1971 - Springer
… Thymidine uptake into the acid-soluble fraction of several hamster cell lines differing in
levels of thymidine kinase was examined. Uptake is correlated directly with the level of this …
levels of thymidine kinase was examined. Uptake is correlated directly with the level of this …
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