… hydrophobic pockets, transcription factors have proven among … and specific inhibitors of
human transcription factors have not … antagonist of an oncogenic transcription factor, NOTCH1. …

… for transcription factors challenging. Here, we review some of the most recent developments
for small molecule inhibitors of transcription factors … so far on transcription factors recently …

… , inhibition of transcription factor–DNA binding and modulation of levels of transcription factor
… proteasome degradation or by inhibition of regulators of transcription factor expression. In …

… However, transcription factors themselves are usually considered … transcription factor using
small organic molecules. I will focus here on small molecules that inhibit transcription factors …

… We have shown that the NFKB nuclear transcription factor exists in unstimulated pre-B cells
in a cytoplasmic complex with a specific inhibitory protein, IKB. In this complex, NF-KB does …

… Because they inhibit transcription factor activity by forming nonfunctional heterodimers,
we designated them small interfering peptides (siPEPs) in comparison to siRNAs (Figure 1). …

… inhibitors, we show that PU.1 inhibition is effective at … therapeutic interference with transcription
factor–chromatin binding … further development of PU.1 inhibitors as potential therapeutics. …

… Thus, a specific transcription factor would be synthesised in a … of transcription factors act
in a negative manner to inhibit the expression of specific genes. Such inhibition of transcription …

… Regulation of the NF-xB/rel transcription factor and IxB inhibitor system Liou and Baltimore
479 Given the complexity of this large family of transcription factors, the apparent NF-xB/rel …

… We delineate the element in ATF-2 required for inhibition and find, surprisingly, that it is the
bZIP DNA-binding domain. We show further that inhibition involves interaction between the …