Although Trousseau1 was the earliest observer who noted the association between cancer
and thrombosis, it was Billroth2 who first described the presence of tumor cells within a …

An extensive biomedical literature attests to the controversy regarding the significance of
coagulation activation in cancer. It has been known for over a century that thromboembolism …

The high prevalence of hypercoagulative states in cancer patients has been known for more
than a century. Venous thrombosis in gastric cancer was described by Trousseau in 1865 …

The association between thrombosis and cancer is well known and the first description of
venous thrombosis as a complication of malignant disease by Trousseau dates back to …

As solid tumours rely upon the bloodstream to deliver nutrients necessary for growth, it
follows that interference with that supply may compromise tumour growth. Indeed, this …

It must be admitted that we have little sound information about the pathogenesis of either the
thrombotic or the bleeding syndrome that may occur with malignant tumors. For many years …

Recent evidence from both animal studies and clinical trials in human subjects has
supported the long-held notion that local fibrin deposition is important for the growth and …

In 1878, Billroth discovered that tumor cells invest themselves in a fibrin thrombus, and he
hypothesized that fibrin promotes tumor growth and invasion. Since then, many observations …

Abnormal hemostasis is a fundamental property of malignant disease, not merely an
epiphenomenon attributable to therapy or to chronic illness. Many types of tumor cells …

Studies on the role of fibrin in experimental cancer growth should take into account the
following problems: 1) during growth and dissemination of experimental tumours …