The rat α-fetoprotein (afp) gene is controlled by three enhancers whose function depends on
their interaction with liver-enriched transcription factors. The afp enhancer III, located at …

HNF1 is a transcription factor that is required for hepatocyte-specific expression of several
genes, including albumin and fibrinogen. Rat HNF1-encoding cDNAs have recently been …

The human Factor XII gene codes for a serine proteinase synthesized in liver that activates
both the coagulation and the fibrinolytic cascades. The nucleotide sequence analysis of a …

Factor VII (FVII) is the plasma serine protease zymogen which, on binding to its cellular
receptor tissue factor (TF), initiates blood coagulation. A 47-year-old man with no clinical …

Polymorphic variants in the gene encoding factor VII (F7) affect the plasma levels of this
coagulation protein and modify the clinical phenotype of FVII deficiency in some patients. In …

Background: Prothrombin is a key component in blood coagulation. Overexpression of
prothrombin leads to an increased risk of venous thrombosis. Therefore, the study of the …

Transcription factors, such as nuclear receptors, often exist in various forms that are
generated by highly conserved splicing events. Whereas the functional significance of these …

We have identified a point mutation in the promoter of the factor VII gene responsible for a
severe bleeding disorder in a patient from a large French-Canadian family with known …

Aims: The aim of this study was to investigate associations between coronary heart disease
risk and polymorphisms in the coagulation factor (F) VII gene in participants of a large …

Hepatocyte nuclear factor 4 (HNF-4) is an essential positive regulator of a large number of
liver-specific genes. We report here the isolation of three HNF-4 isoforms from a human liver …