We have used recombinant mammalian expression and purification of the factor VII (FVII)
variant Gln 100→ Arg (Q100RFVII) to study FVII deficiency in subjects with this mutation …

Factor VIII is a glycoprotein that is essential for blood coagulation. Although factor VIII mRNA
has been detected in a variety of human tissues, hepatocytes are considered to be the major …

Factor X (FX) is a vitamin K-dependent serine protease zymogen that functions in both the
extrinsic and intrinsic pathways of blood coagulation. In this study, the 5'-flanking region of …

ABSTRACT Three distinct hepatocyte nuclear factor 3 (HNF-3) proteins (α, β and γ) regulate
transcription ofthe transthyretin (TTR) and numerous other liver-specific genes. The HNF-3 …

Abstract Hepatocyte nuclear factor 4 (HNF-4) is an orphan intracellular receptor that appears
to be a key factor in the regulation of energy metabolism. In order to gain greater …

We report a factor VII (FVII) variant, FVIIShinjo, characterized by normal FVII antigen levels
and variable procoagulant activity using tissue thromboplastin from different sources …

It is not known whether the mammalian mechanism of coagulation initiation is conserved in
fish. Identification of factor VII is critical in providing evidence for such a mechanism. A cDNA …

2. Results Fig. 1 reports a sequence map of FVII promoter which contains the new restriction
site location. In the amplified fragment containing the− 323 insertion polymorphism …

We have identified cis-acting elements and trans-acting factors that regulate constitutive
expression of the human antithrombin gene. The activity of the sequences flanking the first …

Abstract Hepatic nuclear factor 4 (HNF4) is a transcription factor whose expression is crucial
for mouse embryonic development, for liver-specific gene expression and for the prevention …