Orphan receptor HNF-4 and liver-specific gene expression.
FM Sladek - Receptor, 1993 - europepmc.org
Hepatocyte nuclear factor 4 (HNF-4), found in liver, kidney, and intestine, is a potent
transcriptional activator that controls the expression of a wide variety of genes, including …
transcriptional activator that controls the expression of a wide variety of genes, including …
Isoforms of hepatocyte nuclear factor-6 differ in DNA-binding properties, contain a bifunctional homeodomain, and define the new ONECUT class of homeodomain …
VJ Lannoy, TR Bürglin, GG Rousseau… - Journal of Biological …, 1998 - ASBMB
Hepatocyte nuclear factor-6 (HNF-6) contains a single cut domain and a homeodomain
characterized by a phenylalanine at position 48 and a methionine at position 50. We …
characterized by a phenylalanine at position 48 and a methionine at position 50. We …
Expression of factor VII in the liver of patients with liver disease: correlations with the disease severity and impairment in the hemostasis
E Rodriguez-Inigo, J Bartolome… - Blood coagulation & …, 2001 - journals.lww.com
Factor VII (FVII) plasma levels in patients with liver disease may be below the normal range.
However, no data are available on FVII expression in liver biopsies from patients with liver …
However, no data are available on FVII expression in liver biopsies from patients with liver …
Age and sex dependent regulation of the factor IX gene in mice
S Kurachi, E Hitomi, K Kurachi - Thrombosis and haemostasis, 1996 - thieme-connect.com
Plasma factor IX and liver factor IX mRNA levels in two normal mouse strains (B6D2F1 and
BALB/CJNIA) were determined in relation to aging and sex of the animals. With male …
BALB/CJNIA) were determined in relation to aging and sex of the animals. With male …
Hepatocyte Nuclear Factor 3β Contains Two Transcriptional Activation Domains, One of Which Is Novel and Conserved with the Drosophila Fork Head Protein
L Pani, DG Overdier, A Porcella, X Qian… - … and cellular biology, 1992 - Taylor & Francis
The hepatocyte nuclear factor 3 (HNF-3) gene family is composed of three proteins (α, β,
and γ) that are transcription factors involved in the coordinate expression of several liver …
and γ) that are transcription factors involved in the coordinate expression of several liver …
Analysis of the partial nucleotide sequences and deduced primary structures of the protease domains of mammalian blood coagulation factors VII and X
M Murakawa, T Okamura, T Kamura… - European journal of …, 1994 - Wiley Online Library
In order to obtain sequence data for the blood coagulation factor VII and factor X in several
mammalian species, we amplified and sequenced the DNA segments of exon VIII from each …
mammalian species, we amplified and sequenced the DNA segments of exon VIII from each …
Hepatic nuclear factor 1-α: inflammation, genetics, and atherosclerosis
AD Armendariz, RM Krauss - Current opinion in lipidology, 2009 - journals.lww.com
Based on the recent genetic findings as well as delineation of the role of HNF1-α in
regulating the expression of the CRP gene, it appears that this transcription factor may play …
regulating the expression of the CRP gene, it appears that this transcription factor may play …
The activity of the activation function 2 of the human hepatocyte nuclear factor 4 (HNF-4α) is differently modulated by F domains from various origins
L SUAUD, P FORMSTECHER, B LAINE - Biochemical Journal, 1999 - portlandpress.com
Hepatocyte nuclear factor 4 (HNF-4) is a member of the nuclear hormone-receptor
superfamily, which plays an important role in the regulation of several genes involved in …
superfamily, which plays an important role in the regulation of several genes involved in …
Disruption of a binding site for hepatocyte nuclear factor 4 results in hemophilia B Leyden.
MJ Reijnen, FM Sladek, RM Bertina… - Proceedings of the …, 1992 - National Acad Sciences
Hemophilia B Leyden is an X chromosome-linked bleeding disorder characterized by very
low plasma levels of blood coagulation factor IX (fIX) during childhood. After puberty, plasma …
low plasma levels of blood coagulation factor IX (fIX) during childhood. After puberty, plasma …
Serine/threonine phosphorylation of orphan receptor hepatocyte nuclear factor 4
G Jiang, L Nepomuceno, Q Yang, FM Sladek - Archives of biochemistry …, 1997 - Elsevier
We showed previously that hepatocyte nuclear factor 4 (HNF-4) defines a new subclass,
Group IV, of nuclear receptors. In order to determine whether members of this subclass are …
Group IV, of nuclear receptors. In order to determine whether members of this subclass are …