Hepatic fibrosis is a pathological lesion, characterized by the progressive accumulation of
extracellular matrix (ECM) in the perisinusoidal space and it is a major problem in chronic …

Activation of hepatic stellate cell (HSC) involves the transition from a quiescent to a
proliferative, migratory, and fibrogenic phenotype (ie, myofibroblast), which is characteristic …

Hepatic stellate cells represent a highly versatile cytotype that plays a significant role in liver
development and differentiation, regeneration, xenobiotic response, immunoregulation …

Hepatic fibrosis is characterized by the pathological accumulation of extracellular matrix
(ECM) in the liver resulting from the persistent liver injury and wound-healing reaction …

Chronic liver injury due to viral hepatitis, alcohol abuse, and metabolic disorders is a
worldwide health concern. Insufficient treatment of chronic liver injury leads to fibrosis …

Activated hepatic stellate cells (aHSC) are the main source of extra cellular matrix in liver
fibrosis. Activation is classically divided in two phases: initiation and perpetuation. Currently …

This review article summarizes 20 years of our research on hepatic stellate cells within the
framework of two collaborative research centers CRC575 and CRC974 at the Heinrich …

Capillarization, lack of liver sinusoidal endothelial cell (LSEC) fenestration, and formation of
an organized basement membrane not only precedes fibrosis, but is also permissive for …

Hepatic stellate cell (HSC) lipid droplets are specialized organelles for the storage of
retinoid, accounting for 50–60% of all retinoid present in the body. When HSCs activate …

Hepatic stellate cells (HSC), a pericyte-like nonparenchymal liver cell population, are
regarded as the principal matrix-synthesizing cells of fibrotic liver. They might also play a …