Promoter and silencer elements of the immediate 5'flanking region of the gene coding for
human factor VII were identified and characterized. The major transcription start site …

The gene encoding murine coagulation factor VII (fVII) has been cloned. Seven introns and
eight exons are present, with the introns positioned as splice junctions between the major …

Factor VII is a vitamin K-dependent coagulation protein essential for proper hemostasis. The
human Factor VII gene spans 13 kilobase pairs and is located on chromosome 13 just 2.8 …

To identify the 5′ sequences of the murine coagulation factor VII (fVII) gene that resulted in
its efficient transcription, a variety of 5′-flanking sequences up to 7 kilobase pairs upstream …

The human coagulation protease factor VII plays a pivotal role in the initiation of the
coagulation cascade by both the extrinsic and the intrinsic pathway. Although the gene …

Functional characterization of the 5'-regulatory region of the human factor IX gene was
carried out by a series of gene dissection analyses. The region extending from-175 to-274 of …

Although small deletions, splice site abnormalities, missense, and nonsense mutations have
been identified in patients with factor VII deficiency, there have been no reports of mutations …

Factor VII (FVII) plasma levels in patients with liver disease may be below the normal range.
However, no data are available on FVII expression in liver biopsies from patients with liver …

Investigation of the molecular basis of a severe factor VII (fVII) deficiency revealed
compound heterozygosity in the fVII gene. On the paternal allele the patient had 3 structural …

Several murine monoclonal anti-human Factor VII antibodies were produced using
hybridoma technology. Two noncompetitive monoclonal antibodies were used to examine …