Evaluation of gastrointestinal pH and gastric residence time via the Heidelberg radiotelemetry capsule: pharmaceutical application

P Mojaverian - Drug development research, 1996 - Wiley Online Library
Abstract The Heidelberg Radiotelemetry Capsule (7 mm diameter x 20 mm length)
represents a noninvasive device to monitor gastrointestinal (GI) pH and to evaluate gastric …

Estimation of gastric residence time of the Heidelberg capsule in humans: effect of varying food composition

P Mojaverian, RK Ferguson, PH Vlasses, ML Rocci Jr… - Gastroenterology, 1985 - Elsevier
In animal and human studies, the gastric emptying of large (> 1 mm) indigestible solids is
due to the activity of the interdigestive migrating myoelectric complex. The gastric residence …

Influence of single and multiple doses of oral ranitidine on the gastric transit of an indigestible capsule in humans

P Mojaverian, PH Vlasses, S Parker… - Clinical Pharmacology …, 1990 - Wiley Online Library
The effect of single and multiple doses of ranitidine on the gastric residence time of an
indigestible pH‐sensitive radiotelemetric device, the Heidelberg capsule, was evaluated in …

Mechanism of gastric emptying of a nondisintegrating radiotelemetry capsule in man

P Mojaverian, JC Reynolds, A Ouyang, F Wirth… - Pharmaceutical …, 1991 - Springer
We studied the mechanism of gastric emptying of a pH-sensitive radiotelemetry capsule with
respect to phases of the interdigestive migrating motor complex (IMMC) in fasting normal …

Gastrointestinal transit of a solid indigestible capsule as measured by radiotelemetry and dual gamma scintigraphy

P Mojaverian, K Chan, A Desai, V John - Pharmaceutical research, 1989 - Springer
The objectives of the present study were to evaluate gastric and small bowel transit times of
an indigestible solid matrix and to characterize the specific changes in intraluminal pH as a …

[HTML][HTML] A technical review and clinical assessment of the wireless motility capsule

RJ Saad, WL Hasler - Gastroenterology & hepatology, 2011 - ncbi.nlm.nih.gov
The wireless motility/pH capsule (WMC) is an orally ingested, nondigestible, data recording
device that enables the simultaneous assessment of regional and whole gut transit …

Gastric pH and gastric residence time in fasted and fed conscious cynomolgus monkeys using the Bravo® pH system

EP Chen, KM Mahar Doan, S Portelli, R Coatney… - Pharmaceutical …, 2008 - Springer
Purpose To measure fasted and fed gastric pH and gastric residence time (GRT) in
Cynomolgus monkeys using Bravo® radiotelemetry capsules. Methods Continuous pH …

pH‐profile and regional transit times of the normal gut measured by a radiotelemetry device

J Fallingborg, LA Christensen… - Alimentary …, 1989 - Wiley Online Library
The pH of the gut lumen was measured in 39 healthy persons using a pH‐sensitive,
radiotransmitting capsule. Thirteen persons were studied twice. The location of the capsule …

Effects of gender, posture, and age on gastric residence time of an indigestible solid: pharmaceutical considerations

P Mojaverian, PH Vlasses, PE Kellner… - Pharmaceutical …, 1988 - Springer
We have recently reported the effect of varying food composition on the gastric residence
time (GRT) of an indigestible solid, the Heidelberg capsule (HC). The purpose of the present …

Regional gastrointestinal transit and pH studied in 215 healthy volunteers using the wireless motility capsule: influence of age, gender, study country and testing …

YT Wang, SD Mohammed, AD Farmer… - Alimentary …, 2015 - Wiley Online Library
Background The wireless motility capsule (WMC) offers the ability to investigate luminal
gastrointestinal (GI) physiology in a minimally invasive manner. Aim To investigate the effect …