Background. Thrombotic vascular occlusion resulting in infarction occurs during hyperacute
rejection of allografts transplanted into sensitized patients and remains a major problem in …

Background. Thrombotic vascular occlusion occurs in disorders of diverse etiology,
including atherosclerosis, vasculitis, and disseminated intravascular coagulation. The same …

Background—Intravascular thrombosis occurs in disorders of diverse pathogeneses,
including allograft and xenograft rejection. In this in vitro study, we describe an approach for …

We have generated transgenic mice expressing the leech anticoagulant hirudin and human
tissue factor pathway inhibitor tethered to the cell surface by fusion with fragments of human …

Aside from their critical role in thrombosis, activated coagulation factors also have
inflammatory properties and these may be important during delayed xenograft rejection …

Background. Delayed xenograft rejection (DXR) is characterized by inflammation and
vascular thrombosis. Activation of coagulation may occur as a result of tissue factor (TF) …

Xenotransplantation promises an unlimited supply of organs for clinical transplantation.
However, an aggressive humoral immune response continues to limit the survival of pig …

22 activated endothelial cells. Hirudin was covalently crosslinked to the monoclonal
antibody H18/7, which rec ognizes the extracellular domain of E-selectin, a normally silent …

Abstract Development of coagulation disorders remains a major challenge in pig‐to‐primate
organ xenotransplantation. Our previous studies demonstrated that porcine aortic …

Background: Intravascular thrombosis remains a barrier to successful xenotransplantation.
Tissue factor (TF) expression on porcine aortic endothelial cells (PAECs), which results from …