The infiltration of monocytes into the CNS represents one of the early steps to inflammatory
events in AIDS-related encephalitis and dementia. Increased activity of selected matrix …

Despite effective antiretroviral therapy (ART), mild forms of HIV-associated neurocognitive
disorders (HAND) continue to afflict approximately half of all people living with HIV (PLWH) …

Astrocyte infection in HIV has been associated with rapid progression of dementia in a
subset of HIV/AIDS patients. Astrogliosis and microglial activation are observed in areas of …

Human immunodeficiency virus type 1 Tat protein is one of the soluble neurotoxins. Most
studies have to date focused on Tat as an extracellular molecule and its role in neuronal …

We investigated the role of the HIV-1 protein Tat in AIDS-associated dementia, by studying
its toxicity on rat cortical and hippocampal neurons in vitro. We evaluated the involvement of …

The pathogenesis of human immunodeficiency virus type 1 (HIV‐1)‐associated dementia is
mediated by neuronal dysfunction and death, brought about by the action of soluble …

The widespread use of combinational antiretroviral therapies (cART) in developed countries
has changed the course of Human Immunodeficiency Virus (HIV) infection from an almost …

Oxidative stress is thought to play a role in the onset of dementia. HIV-dementia has recently
been demonstrated to be associated with oxidative stress as indexed by increased protein …

HIV-1 infection causes, with increasing prevalence, neurological disorders characterized in
part by neuronal cell death. The HIV-1 protein Tat has been shown to be directly and …

HIV-1 Tat is a major culprit for HIV/neuroAIDS. One of the consistent hallmarks of
HIV/neuroAIDS is reactive astrocytes or astrocytosis, characterized by increased cytoplasmic …