There is a renewed interest in obtaining a systemic understanding of metabolism, gene
expression and signal transduction processes, driven by the recent research focus on …

In this study, a class of dynamic models based on metabolic reaction pathways is analyzed,
showing that systems with complex intracellular reaction networks can be represented by …

Abstract Systems biology aims at creating mathematical models, ie, computational
reconstructions of biological systems and processes that will result in a new level of …

With more and more interest in how components of biological systems interact, it is important
to understand the various aspects of systems biology. Kinetic Modelling in Systems Biology …

The complexity of the regulatory network and the interactions that occur in the intracellular
environment of microorganisms highlight the importance in developing tractable mechanistic …

The Human Genome Project, DNA microarrays, proteome chips and metabolic profiles,
among others, are generating unprecedented amounts of valuable information about the …

Mathematical modeling and computational analyses of biological systems generally pose to
modelers questions like:“Which modeling approach is suitable to describe the system we …

An inherent problem in studying the behavior of a metabolic pathway is the impossibility of
developing a complete, detailed model that includes all the cellular processes that have an …

Recent trends suggest that future biotechnology will increasingly rely on mathematical
models of the biological systems under investigation. In particular, metabolic engineering …

In this study, a class of dynamic models based on metabolic reaction pathways is analyzed,
showing that systems with complex intracellular reaction networks can be represented by …