Arachidonic acid can be oxidatively metabolized by cytochrome P450 epoxygenase to four
regioisomeric epoxyeichosatrienoic acids (5, 6-; 8, 9-; 11, 12-; 14, 15-EET), which exhibit …

Epoxyeicosatrienoic acids (EETs) are endothelium-derived arachidonic acid metabolites of
cytochrome P450. They dilate coronary arteries, open K+ channels, and hyperpolarize …

Arachidonic acid (AA) can be metabolized to epoxides and their corresponding diols via the
cytochrome P450 epoxygenase pathway. We have compared the vascular activity of four …

The present study examined the effects of 20-hydroxyeicosatetraenoic acid (20-HETE) and
17-octadecynoic acid (17-ODYA), an inhibitor of the metabolism of arachidonic acid by P …

Although epoxyeicosatrienoic acids, cytochrome P-450 mono-oxygenase metabolites of
arachidonic acid, have been demonstrated to play a crucial role in endothelial cell Ca2+ …

Epoxyeicosatrienoic acids (EETs), products of the cytochrome P-450 monooxygenase
metabolism of arachidonic acid, can regulate the activity of ion channels. We examined the …

P450-dependent arachidonic acid (AA) metabolites regulate arterial tone by modulating
calcium-activated (BK) potassium channels in vascular smooth muscle cells (VSMC) …

Epoxyeicosatrienoic acids (EETs), the cytochrome P-450 epoxygenase metabolites of
arachidonic acid, are candidates of endothelium-derived hyperpolarizing factors. We have …

Recent studies have indicated that arachidonic acid is primarily metabolized by cytochrome
P-450 (CYP) enzymes in the brain, lung, kidney, and peripheral vasculature to 20 …

Epoxyeicosatrienoic acids (EETs) are cytochrome P450–derived metabolites of arachidonic
acid. They are potent endogenous vasodilator compounds produced by vascular cells, and …