The in vitro dissolution profiles of deramciclane 30 mg film-coated tablets, an acid-labile new
5-HT receptor antagonist, were studied under simulated fasting and fed conditions. Artificial …

The effect of a high-fat meal on the oral bioavailability of deramciclane 30 mg tablet was
evaluated in 18 healthy male volunteers in a randomised, single dose, two-way crossover …

Individual pharmacokinetics after administration of enteric coated tablets are often highly
variable and this has been ascribed to the interaction of the dosage form with the physiology …

Generic drugs offer a cost-effective alternative to brand-name products. However, the main
concern with modified-release formulations is the substitution of one product for another …

The objective of this research was to characterize the dissolution profile of a poorly soluble
drug, diclofenac, from a commercially available multiple-unit enteric coated dosage form …

The aim of this research was to simulate oral pharmacokinetic (PK) profiles of atorvastatin
from orally disintegrating tablets (ODTs) dosed without water ingestion in fasted humans …

Quantitative evaluation of drug dissolution characteristics based on mathematical models is
essential to understand and predict a particular drug release profile. In this study, model …

The establishment of physiologically relevant in vitro–in vivo correlations (IV–IVCs) is key for
any biorelevant dissolution test. Historically, bicarbonate buffers have produced better …

Prediction of the in vivo performance of the drug product from the in vitro studies is the major
challenging job for the pharmaceutical industries. From the current regulatory perspective …

The availability of biorelevant methods for the disintegration study of pharmaceutical
orodispersible dosage forms is required. The disintegration of orodispersibles should be …