Recent studies have indicated that arachidonic acid is primarily metabolized by cytochrome
P-450 (CYP) enzymes in the brain, lung, kidney, and peripheral vasculature to 20 …

Epoxyeicosatrienoic acids (EETs) are considered to be endothelium-derived
hyperpolarizing factors, and are potent activators of the large-conductance, Ca2+-activated …

Cytochrome P450 (CYP) epoxygenases convert arachidonic acid to four
epoxyeicosatrienoic acid (EET) regioisomers, 5, 6-, 8, 9-, 11, 12-, and 14, 15-EET, that …

Epoxyeicosatrienoic acids (EETs), products of the cytochrome P-450 monooxygenase
metabolism of arachidonic acid, can regulate the activity of ion channels. We examined the …

Recent studies from our laboratory have indicated that vascular smooth muscle cells
(VSMC) metabolize arachidonic acid via a P4504A-dependent pathway to 20 …

The three major enzyme systems, cyclo-oxygenase, lipoxygenase, and cytochrome P450
(P450/CYP), metabolize arachidonic acid (AA) to biologically active compounds. P450 and …

Arachidonic acid (AA) is metabolized by cytochrome P450 (CYP)‐dependent pathways to
epoxyeicosatrienoic acids (EET) and 20‐hydroxyeicosatetraenoic acid (20‐HETE) in the …

1 Dihydroxyeicosatrienoic acids (DHETs), which are metabolites of arachidonic acid (AA)
and epoxyeicosatrienoic acids (EETs), have been identified as highly potent endogenous …

Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites of cytochrome P450
monooxygenase, which are released from endothelial cells and dilate arteries. Dilation …

Abstract Cytochrome P450s (P450) metabolize arachidonic acid (AA) to
hydroxyeicosatetraenoic acids (HETEs) and epoxyeicosatrienoic acids (EETs). Among these …