Arachidonic acid metabolism via cyclooxygenase, lipoxygenase, and cytochrome P-450
epoxygenase was investigated in thoracic aortic tissue obtained from rabbits fed either …

The present study examined the effects of 11, 12-and 14, 15-epoxyeicosatrienoic acids
(EETs) on the diameter of small renal arteries of the rat and assessed their action on K (+) …

Epoxyeicosatrienoic acids (EETs), synthesized and released by astrocytes in response to
glutamate, are known to play a pivotal role in neurovascular coupling. In vascular smooth …

Considerable evidence has accumulated over the last decade implicating a role of
cytochrome P450 (CYP)-dependent metabolites of arachidonic acid (AA) in the …

Arachidonic acid (AA) can be metabolized to epoxides and their corresponding diols via the
cytochrome P450 epoxygenase pathway. We have compared the vascular activity of four …

Epoxyeicosatrienoic acids (EETs), which are synthesized from arachidonic acid by
cytochrome P450 epoxygenases, function primarily as autocrine and paracrine effectors in …

Endothelial and vascular smooth cells generate cytochrome P450 (CYP) arachidonic acid
metabolites that can impact endothelial cell function and vascular homeostasis. The …

Cytochrome P450 (CYP)-dependent metabolites of arachidonic acid (AA) contribute to the
regulation of cardiovascular function. CYP enzymes also accept EPA and DHA to yield more …

Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid to generate
epoxyeicosatrienoic acids (EETs). The latter are biologically active and reported to act as an …

The endothelium regulates vascular tone through the release of a number of soluble
mediators, including NO, prostaglandin I2, and endothelium-derived hyperpolarizing factor …