17 (R), 18 (S)-Epoxyeicosatetraenoic acid [17 (R), 18 (S)-EETeTr], a cytochrome P450
epoxygenase metabolite of eicosapentaenoic acid (EPA), exerts negative chronotropic …

The endothelium regulates vascular tone through the release of a number of soluble
mediators, including NO, prostaglandin I2, and endothelium-derived hyperpolarizing factor …

The development of pharmacological, genetic, and biochemical tools have allowed for
detailed studies to determine the contribution of cytochrome P450 (CYP) metabolites of …

Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid via cytochrome P450
(CYP)/epoxygenases. EETs possess cardioprotective properties and are catalyzed by …

Polyunsaturated fatty acids (PUFA) are oxidized by cytochrome P450 epoxygenases to
PUFA epoxides which function as potent lipid mediators. The major metabolic pathways of …

Hypertension is often characterised by impaired vasodilation involving dysfunction of
multiple vasodilatory mechanisms. ω‐3 polyunsaturated fatty acids (PUFAs) …

The P450 eicosanoids epoxyeicosatrienoic acids (EETs) are endogenous lipid mediators
produced in the brain by P450 epoxygenases and metabolized through multiple pathways …

Recent studies indicate that arachidonic acid is primarily metabolized by cytochrome P450
enzymes of the 4A and 2C families in the kidney to 20-hydroxyeicosatetraenoic acid (HETE) …

Numerous benefits have been attributed to dietary long-chain omega-3 polyunsaturated fatty
acids (n-3 LC-PUFAs), including protection against cardiac arrhythmia, triglyceride-lowering …

Adrenic acid (docosatetraenoic acid), an abundant fatty acid in the vasculature, is produced
by a two-carbon chain elongation of arachidonic acid. Despite its abundance and similarity …