Therapeutic potential of omega-3 fatty acid-derived epoxyeicosanoids in cardiovascular and inflammatory diseases
WH Schunck, A Konkel, R Fischer… - Pharmacology & …, 2018 - Elsevier
Numerous benefits have been attributed to dietary long-chain omega-3 polyunsaturated fatty
acids (n-3 LC-PUFAs), including protection against cardiac arrhythmia, triglyceride-lowering …
acids (n-3 LC-PUFAs), including protection against cardiac arrhythmia, triglyceride-lowering …
Relaxing effects of 17 (18)-EpETE on arterial and airway smooth muscles in human lung
C Morin, M Sirois, V Echave… - American Journal of …, 2009 - journals.physiology.org
Human cytochrome P-450 epoxygenase enzymes metabolize eicosapentaenoic acid (EPA),
an ω-3-polyunsaturated fatty acid (PUFA), and leads to the production of 17 (18) …
an ω-3-polyunsaturated fatty acid (PUFA), and leads to the production of 17 (18) …
Anti-inflammatory effects of ω-3 polyunsaturated fatty acids and soluble epoxide hydrolase inhibitors in angiotensin-II–dependent hypertension
A Ulu, TR Harris, C Morisseau, C Miyabe… - Journal of …, 2013 - journals.lww.com
The mechanisms underlying the anti-inflammatory and antihypertensive effects of long-chain
ω-3 polyunsaturated fatty acids (ω-3 PUFAs) are still unclear. The epoxides of an ω-6 fatty …
ω-3 polyunsaturated fatty acids (ω-3 PUFAs) are still unclear. The epoxides of an ω-6 fatty …
Kidney CYP450 enzymes: biological actions beyond drug metabolism
X Zhao, JD Imig - Current drug metabolism, 2003 - ingentaconnect.com
Arachidonic acid can be metabolized by cytochrome P450 (CYP450) enzymes to 5, 6-, 8, 9-,
11, 12-, and 14, 15-epoxyeicosatrienoic acids (EETs), their corresponding …
11, 12-, and 14, 15-epoxyeicosatrienoic acids (EETs), their corresponding …
[HTML][HTML] Epoxyeicosatrienoic acids act through TRPV4–TRPC1–KCa1. 1 complex to induce smooth muscle membrane hyperpolarization and relaxation in human …
Y Ma, P Zhang, J Li, J Lu, J Ge, Z Zhao, X Ma… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Human left internal mammary arteries (LIMAs) are commonly used as donor grafts for
coronary bypass surgery. Previous reports suggested that 11, 12-epoxyeicosatrienoic acid …
coronary bypass surgery. Previous reports suggested that 11, 12-epoxyeicosatrienoic acid …
19,20-EpDPE, a bioactive CYP450 metabolite of DHA monoacyglyceride, decreases Ca2+ sensitivity in human pulmonary arteries
C Morin, S Fortin, E Rousseau - American Journal of …, 2011 - journals.physiology.org
The aim of this study was to investigate the effect of docosahexaenoic acid
monoacylglyceride (MAG-DHA) on human pulmonary arterial tone. Tension measurements …
monoacylglyceride (MAG-DHA) on human pulmonary arterial tone. Tension measurements …
Metabolic profiling of murine plasma reveals eicosapentaenoic acid metabolites protecting against endothelial activation and atherosclerosis
Y Liu, X Fang, X Zhang, J Huang, J He… - British Journal of …, 2018 - Wiley Online Library
Background and Purpose Atherosclerosis results from a maladaptive inflammatory response
initiated by the intramural retention of LDL in susceptible areas of the arterial vasculature …
initiated by the intramural retention of LDL in susceptible areas of the arterial vasculature …
Epoxide hydrolases regulate epoxyeicosatrienoic acid incorporation into coronary endothelial phospholipids
NL Weintraub, X Fang, TL Kaduce… - American Journal …, 1999 - journals.physiology.org
Cytochrome P-450-derived epoxyeicosatrienoic acids (EETs) are avidly incorporated into
and released from endothelial phospholipids, a process that results in potentiation of …
and released from endothelial phospholipids, a process that results in potentiation of …
CYP-eicosanoids—a new link between omega-3 fatty acids and cardiac disease?
C Westphal, A Konkel, WH Schunck - Prostaglandins & other lipid …, 2011 - Elsevier
Fish oil omega-3 fatty acids such as eicosapentaenoic acid (EPA) and docosahexaenoic
acid (DHA) protect against arrhythmia and sudden cardiac death by largely unknown …
acid (DHA) protect against arrhythmia and sudden cardiac death by largely unknown …
Calcium-mediated mechanisms of eicosapentaenoic acid-induced relaxation in hypertensive rat aorta
MB Engler, YH Ma, MM Engler - American journal of …, 1999 - academic.oup.com
We have previously demonstrated the vasorelaxant properties of the omega-3 fatty acid,
eicosapentaenoic acid (EPA), in normotensive and spontaneously hypertensive rat (SHR) …
eicosapentaenoic acid (EPA), in normotensive and spontaneously hypertensive rat (SHR) …