Stable 5, 6-epoxyeicosatrienoic acid analog relaxes coronary arteries through potassium channel activation
W Yang, KM Gauthier, LM Reddy, B Sangras… - …, 2005 - Am Heart Assoc
5, 6-Epoxyeicosatrienoic acid (5, 6-EET) is a cytochrome P450 epoxygenase metabolite of
arachidonic acid that causes vasorelaxation. However, investigations of its role in biological …
arachidonic acid that causes vasorelaxation. However, investigations of its role in biological …
Characterization of 14, 15-epoxyeicosatrienoyl-sulfonamides as 14, 15-epoxyeicosatrienoic acid agonists: use for studies of metabolism and ligand binding
W Yang, BB Holmes, VR Gopal, RVK Kishore… - … of Pharmacology and …, 2007 - ASPET
Epoxyeicosatrienoic acids (EETs) are cytochrome P450 epoxygenase metabolites of
arachidonic acid. EETs mediate numerous biological functions. In coronary arteries, they …
arachidonic acid. EETs mediate numerous biological functions. In coronary arteries, they …
14, 15-Dihydroxy-eicosa-5 (Z)-enoic acid selectively inhibits 14, 15-epoxyeicosatrienoic acid-induced relaxations in bovine coronary arteries
IA Bukhari, KM Gauthier, SG Jagadeesh… - … of Pharmacology and …, 2011 - ASPET
Cytochrome P-450 epoxygenases metabolize arachidonic acid (AA) to epoxyeicosatrienoic
acids (EETs). EETs relax vascular smooth muscle by membrane hyperpolarization. 14, 15 …
acids (EETs). EETs relax vascular smooth muscle by membrane hyperpolarization. 14, 15 …
Comparison of vasodilatory properties of 14, 15-EET analogs: structural requirements for dilation
JR Falck, UM Krishna, YK Reddy… - American Journal …, 2003 - journals.physiology.org
Epoxyeicosatrienoic acids (EETs) are endothelium-derived eicosanoids that activate
potassium channels, hyperpolarize the membrane, and cause relaxation. We tested 19 …
potassium channels, hyperpolarize the membrane, and cause relaxation. We tested 19 …
14, 15-Epoxyeicosa-5, 8, 11-trienoic acid (14, 15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase …
JR Falck, R Kodela, R Manne, KR Atcha… - Journal of medicinal …, 2009 - ACS Publications
All-cis-14, 15-epoxyeicosa-5, 8, 11-trienoic acid (14, 15-EET) is a labile, vasodilatory
eicosanoid generated from arachidonic acid by cytochrome P450 epoxygenases. A series of …
eicosanoid generated from arachidonic acid by cytochrome P450 epoxygenases. A series of …
11,12,20-Trihydroxy-eicosa-8(Z)-enoic acid: a selective inhibitor of 11,12-EET-induced relaxations of bovine coronary and rat mesenteric arteries
IA Bukhari, AJ Shah, KM Gauthier… - American Journal …, 2012 - journals.physiology.org
Arachidonic acid is metabolized to four regioisomeric epoxyeicosatrienoic acids (EETs) by
cytochrome P-450. 5, 6-, 8, 9-, 11, 12-, and 14, 15-EET are equipotent in relaxing bovine …
cytochrome P-450. 5, 6-, 8, 9-, 11, 12-, and 14, 15-EET are equipotent in relaxing bovine …
20-125Iodo-14, 15-epoxyeicosa-5 (Z)-enoic acid: a high-affinity radioligand used to characterize the epoxyeicosatrienoic acid antagonist binding site
Y Chen, JR Falck, VR Tuniki, WB Campbell - Journal of Pharmacology and …, 2009 - ASPET
Epoxyeicosatrienoic acids (EETs) are endothelium-derived metabolites of arachidonic acid.
They relax vascular smooth muscle by membrane hyperpolarization. These actions are …
They relax vascular smooth muscle by membrane hyperpolarization. These actions are …
Functional implications of a newly characterized pathway of 11, 12-epoxyeicosatrienoic acid metabolism in arterial smooth muscle
X Fang, TL Kaduce, NL Weintraub… - Circulation …, 1996 - Am Heart Assoc
Epoxyeicosatrienoic acids (EETs) are potent vasodilators derived from cytochrome P-450
metabolism of arachidonic acid. The rapid conversion of EETs to their corresponding …
metabolism of arachidonic acid. The rapid conversion of EETs to their corresponding …
14,15-Epoxyeicosa-5(Z)-enoic Acid: A Selective Epoxyeicosatrienoic Acid Antagonist That Inhibits Endothelium-Dependent Hyperpolarization and Relaxation in …
KM Gauthier, C Deeter, UM Krishna, YK Reddy… - Circulation …, 2002 - Am Heart Assoc
Endothelium-dependent hyperpolarization and relaxation of vascular smooth muscle are
mediated by endothelium-derived hyperpolarizing factors (EDHFs). EDHF candidates …
mediated by endothelium-derived hyperpolarizing factors (EDHFs). EDHF candidates …
Action of epoxyeicosatrienoic acids (EETs) on cellular function
AA Spector, AW Norris - Am J Physiol, 2006 - journals.physiology.org
Epoxyeicosatrienoic acids (EETs), which function primarily as autocrine and paracrine
mediators in the cardiovascular and renal systems, are synthesized from arachidonic acid by …
mediators in the cardiovascular and renal systems, are synthesized from arachidonic acid by …