Novel high-throughput techniques are capable of producing dense time series of many
simultaneous in vivo measurements of the expression of genes, concentrations of …

Unlike signalling pathways, metabolic networks are subject to strict stoichiometric
constraints. Metabolomics amplifies changes in the proteome, and represents more closely …

Developing a new drug is a tedious and expensive undertaking. The recently developed
high-throughput experimental technologies, summarised by the terms genomics …

The growth and development in the last decade of accurate and reliable mass data
collection techniques has greatly enhanced our comprehension of cell signaling networks …

This book introduces drug researchers to the novel computational approaches of pathway
analysis and explains the existing applications that can save time and money in the drug …

It is evident that biochemical control is not strictly hierarchical and that intermediary
metabolism can contribute to control of regulatory pathways. Metabolic studies are therefore …

The rapid development of high-throughput experiments in molecular biology over the past
decade has facilitated the generation of metabolic datasets of unprecedented quantity and …

The metabolic syndrome, inborn errors of metabolism, and drug-induced changes to
metabolic states all bring about a seemingly bewildering array of alterations in metabolite …

In spite of the increasing availability of genomic and transcriptomic data, there is still a gap
between the detection of perturbations in gene expression and the understanding of their …

Metabolomics is based on the simultaneous analysis of multiple low-molecular-weight
metabolites from a given sample. The goals of metabolomics are to catalog and quantify the …