A restricted parabrachial pontine region is active during non-rapid eye movement sleep

P Torterolo, S Sampogna, MH Chase - Neuroscience, 2011 - Elsevier
The principal site that generates both rapid eye movement (REM) sleep and wakefulness is
located in the mesopontine reticular formation, whereas non-rapid eye movement (NREM) …

Pontine regulation of REM sleep components in cats: integrity of the pedunculopontine tegmentum (PPT) is important for phasic events but unnecessary for atonia …

MN Shouse, JM Siegel - Brain research, 1992 - Elsevier
Transection, lesion and unit recording studies have localized rapid eye movement (REM)
sleep mechanisms to the pons. Recent work has emphasized the role of pontine cholinergic …

C-fos expression in the pons and medulla of the cat during carbachol-induced active sleep

J Yamuy, JR Mancillas, FR Morales… - Journal of …, 1993 - Soc Neuroscience
Microinjection of carbachol into the rostral pontine tegmentum of the cat induces a state that
is comparable to naturally occurring active (REM, rapid eye movement) sleep. We sought to …

Time course of Fos-like immunoreactivity associated with cholinergically induced REM sleep

PJ Shiromani, M Malik, S Winston… - Journal of …, 1995 - Soc Neuroscience
Now that the pharmacology and neuronal connectivity underlying REM sleep is beginning to
be understood, it is important to begin investigations that elucidate the transcriptional …

Selective enhancement of rapid eye movement sleep by deep brain stimulation of the human pons

AS Lim, E Moro, AM Lozano, C Hamani… - Annals of Neurology …, 2009 - Wiley Online Library
Animal studies suggest that rapid eye movement (REM) sleep is governed by the interaction
of REM‐promoting and REM‐inhibiting nuclei in the pontomesencephalic tegmentum. The …

[HTML][HTML] REM sleep at its core–circuits, neurotransmitters, and pathophysiology

JJ Fraigne, ZA Torontali, MB Snow… - Frontiers in neurology, 2015 - frontiersin.org
Rapid eye movement (REM) sleep is generated and maintained by the interaction of a
variety of neurotransmitter systems in the brainstem, forebrain, and hypothalamus. Within …

Pontine cholinergic neurons show Fos-like immunoreactivity associated with cholinergically induced REM sleep

PJ Shiromani, S Winston, RW McCarley - Molecular brain research, 1996 - Elsevier
Recently, we showed c-fos expression in pontine nuclei in association with cholinergically
induced REM sleep (REMc). Pontine cholinergic mechanisms have been implicated in the …

Cholinergically induced REM sleep triggers Fos-like immunoreactivity in dorsolateral pontine regions associated with REM sleep

PJ Shiromani, TS Kilduff, FE Bloom, RW McCarley - Brain research, 1992 - Elsevier
We sought to determine the presence of Fos-like immunoreactive (Fos-LI) cells in the
pontine brainstem following cholinergically induced sustained rapid-eye movement (REMc) …

Fos expression in pontomedullary catecholaminergic cells following rapid eye movement sleep-like episodes elicited by pontine carbachol in urethane-anesthetized …

I Rukhadze, VB Fenik, JL Branconi, L Kubin - Neuroscience, 2008 - Elsevier
Pontine noradrenergic neurons of the locus coeruleus (LC) and sub-coeruleus (SubC)
region cease firing during rapid eye movement sleep (REMS). This plays a permissive role …

Preoptic area neurons and the homeostatic regulation of rapid eye movement sleep

I Gvilia, A Turner, D McGinty… - Journal of …, 2006 - Soc Neuroscience
The median preoptic nucleus (MnPN) and the ventral lateral preoptic area (vlPOA) of the
hypothalamus express sleep-related Fos immunoreactivity, and a subset of Fos …