The urokinase plasminogen activator receptor (uPAR) has been implicated in the growth,
metastasis, and angiogenesis of several solid and hemotologic malignancies. uPAR is part …

The urokinase-type plasminogen activator receptor (uPAR) is released from human cancers
and is readily detected in blood. In animal models, soluble uPAR (SuPAR) antagonizes …

Simple Summary Discovered more than three decades ago, the urokinase-type
plasminogen activator receptor (uPAR) has now firmly established itself as a versatile …

Elevated level of urokinase receptor (uPAR) is detected in various aggressive cancer types
and is closely associated with poor prognosis of cancers. Binding of uPA to uPAR triggers …

The urokinase plasminogen activator receptor (uPAR) mediates cell motility and tissue
remodeling. Although uPAR may be expressed transiently in many tissues during …

Simple Summary The uPA/uPAR system is highly involved in cancer progression and
metastasis. Many studies have definitively assessed that the high expression of urokinase …

Proteolysis is a key event in several biological processes; proteolysis must be tightly
controlled because its improper activation leads to dramatic consequences. Deregulation of …

Plasma membrane urokinase-type plasminogen activator (uPA)-receptor (uPAR) is a GPI-
anchored protein that binds with high-affinity and activates the serine protease uPA, thus …

Proteolysis is a key event in several biological processes; proteolysis must be tightly
controlled because its improper activation leads to dramatic consequences. Deregulation of …

The urokinase receptor (uPAR) promotes metastasis of human malignancies; however, its
mechanism of action remains incompletely understood. Established models focus on the …