The Cryptococcus neoformans STE11α gene is similar to other fungal mitogen‐activated protein kinase kinase kinase (MAPKKK) genes but is mating type specific

DL Clarke, GL Woodlee, CM McClelland… - Molecular …, 2001 - Wiley Online Library
Partial sequence analysis of the Cryptococcus neoformans MATα mating type locus
revealed the presence of a gene with substantial sequence similarity to other fungal mitogen …

The Cryptococcus neoformans STE12α gene: a putative Saccharomyces cerevisiae STE12 homologue that is mating type specific

BL Wickes, U Edman, JC Edman - Molecular microbiology, 1997 - Wiley Online Library
Cryptococcus neoformans possesses two mating types, MATα and MATa. α‐Cells are more
virulent than a‐cells and are also, unlike a‐cells, capable of producing extensive hyphae in …

A MAP kinase cascade composed of cell type specific and non‐specific elements controls mating and differentiation of the fungal pathogen Cryptococcus neoformans

RC Davidson, CB Nichols, GM Cox… - Molecular …, 2003 - Wiley Online Library
Cryptococcus neoformans is an opportunistic fungal pathogen with a defined sexual cycle in
which the α allele of the mating type locus is linked to virulence and haploid differentiation …

Ste50 adaptor protein governs sexual differentiation of Cryptococcus neoformans via the pheromone-response MAPK signaling pathway

KW Jung, SY Kim, LH Okagaki, K Nielsen… - Fungal Genetics and …, 2011 - Elsevier
The mitogen-activated protein kinase (MAPK) pathways control diverse cellular functions in
pathogenic fungi, including sexual differentiation, stress response, and maintenance of cell …

Mapping of the Cryptococcus neoformans MATα Locus: Presence of Mating Type-Specific Mitogen-Activated Protein Kinase Cascade Homologs

M Karos, YC Chang, CM McClelland… - Journal of …, 2000 - Am Soc Microbiol
In this study we investigated the relationship between the MAT α locus of Cryptococcus
neoformans and several MAT α-specific mitogen-activated protein (MAP) kinase signal …

Mating-Type-Specific and Nonspecific PAK Kinases Play Shared and Divergent Roles in Cryptococcus neoformans

P Wang, CB Nichols, KB Lengeler, ME Cardenas… - Eukaryotic …, 2002 - Am Soc Microbiol
Cryptococcus neoformans is an opportunistic fungal pathogen with a defined sexual cycle
involving fusion of haploid MAT α and MAT a cells. Virulence has been linked to the mating …

Cryptococcus neoformans STE12α Regulates Virulence but Is Not Essential for Mating

YC Chang, BL Wickes, GF Miller, LA Penoyer… - The Journal of …, 2000 - rupress.org
The Cryptococcus neoformans STE12 α gene, a homologue of Saccharomyces cerevisiae
STE12, exists only in mating type (MAT) α cells. In S. cerevisiae, STE12 was required for …

Identification of the MATa mating-type locus of Cryptococcus neoformans reveals a serotype A MATa strain thought to have been extinct

KB Lengeler, P Wang, GM Cox… - Proceedings of the …, 2000 - National Acad Sciences
Cryptococcus neoformans is an opportunistic fungal pathogen with a defined sexual cycle
involving mating between haploid MATa and MATα cells. Here we describe the isolation of …

Cyclic AMP-dependent protein kinase catalytic subunits have divergent roles in virulence factor production in two varieties of the fungal pathogen Cryptococcus …

JK Hicks, CA D'Souza, GM Cox, J Heitman - Eukaryotic Cell, 2004 - Am Soc Microbiol
Our earlier findings established that cyclic AMP-dependent protein kinase functions in a
signaling cascade that regulates mating and virulence of Cryptococcus neoformans var …

Insertional mutagenesis combined with an inducible filamentation phenotype reveals a conserved STE50 homologue in Cryptococcus neoformans that is required …

J Fu, C Mares, A Lizcano, Y Liu… - Molecular …, 2011 - Wiley Online Library
Cryptococcus neoformans typically grows in a yeast‐like morphology; however, under
specific conditions the fungus can produce hyphae that are either dikaryotic or …