The basidiomycete fungus Cryptococcus neoformans infects humans via inhalation of
desiccated yeast cells or spores from the environment. In the absence of effective immune …

Upon Cryptococcus neoformans infection of the host lung, the fungus enters a nutrient poor
environment and must adapt to a variety of host-specific stress conditions (temperature …

The pathogenic fungus Cryptococcus neoformans generally initiates infection in mammalian
lung tissue and subsequently disseminates to the brain. We performed serial analysis of …

Phagocytosis is a receptor-mediated process that leads to the internalization of foreign
particles into phagocytic cells. Phagocytic cells, such as macrophages, dendritic cells, and …

The fungal pathogen Cryptococcus neoformans survives phagocytosis by macrophages and
proliferates within, ultimately establishing latent infection as a facultative intracellular …

Background Cryptococcus neoformans is an encapsulated yeast that is a facultative
intracellular pathogen. The interaction between macrophages and C. neoformans is critical …

The human fungal pathogen Cryptococcus neoformans is able to rapidly and effectively
adapt to varying conditions, favoring its survival in the environment and in the infected host …

Virulence of Cryptococcus neoformans for mammals, and in particular its intracellular style,
was proposed to emerge from evolutionary pressures on its natural environment by …

Cryptococcus neoformans is a fungal pathogen that causes almost half a million deaths
each year. It is believed that most humans are infected with C. neoformans, possibly in a …

ABSTRACT A library of more than 4,500 signature-tagged insertion mutants of the human
pathogenic fungus Cryptococcus neoformans was generated, and a subset was screened in …