Alzheimer's disease, the commonest cause of dementia, is a growing global health concern
with huge implications for individuals and society. In this review, current understanding of …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with two hallmarks: β‐
amyloid plagues and neurofibrillary tangles. It is one of the most alarming illnesses to elderly …

On the 100 th anniversary of Alzheimer's lecture describing the clinicopathological entity
which bears his eponym, this article reviews the major areas of progress in our …

The amyloid cascade hypothesis, which posits that the deposition of the amyloid-β peptide
in the brain is a central event in Alzheimer's disease pathology, has dominated research for …

The 'amyloid cascade hypothesis' links amyloid β peptide (Aβ) with the pathological process
of Alzheimer's disease (AD) and it still awaits universal acceptance. Amyloid precursor …

An unresolved debate in Alzheimer's disease (AD) is whether amyloid plaques are
pathogenic, causing overt physical disruption of neural circuits, or protective, sequestering …

Alzheimer's disease is of major concern all over the world due to a number of factors
including (i) an aging population (ii) increasing life span and (iii) lack of effective …

Alzheimer's disease is the single biggest unmet medical need in neurology. Current drugs
are safe, but of limited benefit to most patients. This review discusses the scientific basis and …

Alzheimer's disease is a progressive neurodegenerative disease for which no cure exists.
There is a substantial need for new therapies that offer improved symptomatic benefit and …

Converging lines of evidence implicate the beta‐amyloid peptide (Aβ) as causative in
Alzheimer's disease. We describe a novel class of compounds that reduce Aβ production by …