Ras1 controls pheromone expression and response during mating in Cryptococcus neoformans

MS Waugh, MA Vallim, J Heitman… - Fungal Genetics and …, 2003 - Elsevier
The Cryptococcus neoformans Ras1 signal transduction pathway controls mating, hyphal
differentiation, and the ability of this opportunistic human fungal pathogen to grow at …

A Rac Homolog Functions Downstream of Ras1 To Control Hyphal Differentiation and High-Temperature Growth in the Pathogenic Fungus Cryptococcus neoformans

MA Vallim, CB Nichols, L Fernandes, KL Cramer… - Eukaryotic …, 2005 - Am Soc Microbiol
ABSTRACT The Cryptococcus neoformans Ras1 protein serves as a central regulator for
several signaling pathways. Ras1 controls the induction of the mating pheromone response …

Ras1 and Ras2 contribute shared and unique roles in physiology and virulence of Cryptococcus neoformans

MS Waugh, CB Nichols, CM DeCesare… - …, 2002 - microbiologyresearch.org
The Ras1 signal transduction pathway controls the ability of the pathogenic fungus
Cryptococcus neoformans to grow at high temperatures and to mate. A second RAS gene …

Mutation of the Regulator of G Protein Signaling Crg1 Increases Virulence in Cryptococcus neoformans

P Wang, J Cutler, J King, D Palmer - Eukaryotic Cell, 2004 - Am Soc Microbiol
The regulator of G protein signaling homolog Crg1 was found to be a key regulator of
pheromone-responsive mating in the opportunistic human fungal pathogen Cryptococcus …

RAS1 regulates filamentation, mating and growth at high temperature of Cryptococcus neoformans

JA Alspaugh, LM Cavallo, JR Perfect… - Molecular …, 2000 - Wiley Online Library
Cryptococcus neoformans is a basidiomycete yeast and opportunistic human pathogen of
increasing clinical importance due to the increasing population of immunocompromised …

A MAP kinase cascade composed of cell type specific and non‐specific elements controls mating and differentiation of the fungal pathogen Cryptococcus neoformans

RC Davidson, CB Nichols, GM Cox… - Molecular …, 2003 - Wiley Online Library
Cryptococcus neoformans is an opportunistic fungal pathogen with a defined sexual cycle in
which the α allele of the mating type locus is linked to virulence and haploid differentiation …

The G-Protein β Subunit GPB1 Is Required for Mating and Haploid Fruiting in Cryptococcus neoformans

P Wang, JR Perfect, J Heitman - Molecular and Cellular Biology, 2000 - Taylor & Francis
Cryptococcus neoformans is an opportunistic fungal pathogen with a defined sexual cycle.
The gene encoding a heterotrimeric G-protein β subunit, GPB1, was cloned and disrupted …

Cryptococcus neoformans mating and virulence are regulated by the G-protein α subunit GPA1 and cAMP

JA Alspaugh, JR Perfect, J Heitman - Genes & development, 1997 - genesdev.cshlp.org
This study explores signal transduction pathways that function during mating and infection in
the opportunistic, human fungal pathogen Cryptococcus neoformans. The gene encoding a …

Pheromones Stimulate Mating and Differentiation via Paracrine and Autocrine Signaling in Cryptococcus neoformans

WC Shen, RC Davidson, GM Cox, J Heitman - Eukaryotic cell, 2002 - Am Soc Microbiol
Cryptococcus neoformans is a pathogenic fungus with a defined sexual cycle involving
haploid MAT α and MAT a cells. Interestingly, MAT α strains are more common, are more …

Ste50 adaptor protein governs sexual differentiation of Cryptococcus neoformans via the pheromone-response MAPK signaling pathway

KW Jung, SY Kim, LH Okagaki, K Nielsen… - Fungal Genetics and …, 2011 - Elsevier
The mitogen-activated protein kinase (MAPK) pathways control diverse cellular functions in
pathogenic fungi, including sexual differentiation, stress response, and maintenance of cell …