Cryptococcus neoformans Virulence Is Enhanced after Growth in the Genetically Malleable Host Dictyostelium discoideum

JN Steenbergen, JD Nosanchuk… - Infection and …, 2003 - Am Soc Microbiol
Cryptococcus neoformans is an encapsulated, environmental fungus that can cause life-
threatening meningitis. Pathogenicity of C. neoformans for macrophages and vertebrate …

Identification of Virulence Mutants of the Fungal Pathogen Cryptococcus neoformans Using Signature-Tagged Mutagenesis

RT Nelson, J Hua, B Pryor, JK Lodge - Genetics, 2001 - academic.oup.com
Cryptococcus neoformans var. neoformans is an important opportunistic fungal pathogen of
patients whose immune system has been compromised due to viral infection, antineoplastic …

Cryptococcus neoformans var. gattii can exploit Acanthamoeba castellanii for growth

SD Malliaris, JN Steenbergen… - Medical mycology, 2004 - academic.oup.com
It has recently been proposed that the origin and maintenance of virulence in certain
environmental fungi is influenced by their interactions with non-vertebrate hosts such as …

The Biology of the Cryptococcus neoformans Species Complex

X Lin, J Heitman - Annu. Rev. Microbiol., 2006 - annualreviews.org
Cryptococcus neoformans is a major cause of fungal meningoencephalitis in
immunocompromised patients. Despite recent advances in the genetics and molecular …

Evidence that the Human Pathogenic Fungus Cryptococcus neoformans var. grubii May Have Evolved in Africa

AP Litvintseva, I Carbone, J Rossouw, R Thakur… - PLoS …, 2011 - journals.plos.org
Most of the species of fungi that cause disease in mammals, including Cryptococcus
neoformans var. grubii (serotype A), are exogenous and non-contagious. Cryptococcus …

Congenic strains of the filamentous form of Cryptococcus neoformans for studies of fungal morphogenesis and virulence

B Zhai, P Zhu, D Foyle, S Upadhyay… - Infection and …, 2013 - Am Soc Microbiol
Cryptococcus neoformans is an unconventional dimorphic fungus that can grow either as a
yeast or in a filamentous form. To facilitate investigation of genetic factors important for its …

Recapitulation of the Sexual Cycle of the Primary Fungal Pathogen Cryptococcus neoformans var. gattii: Implications for an Outbreak on Vancouver Island, Canada

JA Fraser, RL Subaran, CB Nichols, J Heitman - Eukaryotic cell, 2003 - Am Soc Microbiol
Cryptococcus neoformans is a human fungal pathogen that exists as three distinct varieties
or sibling species: the predominantly opportunistic pathogens C. neoformans var …

The interplay of phenotype and genotype in Cryptococcus neoformans disease

S Altamirano, KM Jackson, K Nielsen - Bioscience Reports, 2020 - portlandpress.com
Cryptococcus neoformans is an opportunistic fungal pathogen that causes life-threatening
meningitis primarily in immunocompromised individuals. In order to survive and proliferate …

Cryptococcus neoformans α Strains Preferentially Disseminate to the Central Nervous System during Coinfection

K Nielsen, GM Cox, AP Litvintseva… - Infection and …, 2005 - Am Soc Microbiol
Cryptococcus neoformans is a fungal pathogen that has evolved over the past 40 million
years into three distinct varieties or sibling species (gattii, grubii, and neoformans). Each …

A Multi-Host Approach for the Systematic Analysis of Virulence Factors in Cryptococcus neoformans

A Desalermos, X Tan, R Rajamuthiah… - The Journal of …, 2015 - academic.oup.com
A multi-host approach was followed to screen a library of 1201 signature-tagged deletion
strains of Cryptococcus neoformans mutants to identify previously unknown virulence …