Intradermal (id) injection of cytokines, IL‐1β and TNFα (5 ng, 60 and 30 min prior) produces
a rapid onset up‐regulation of des‐Arg9‐BK‐mediated rat paw oedema. Here we analyse …

The modulatory effects of IL-1β and TNFα on the rat paw edema induced by B1 agonists
have been analyzed. In naive rats, ID injection of B1 agonists, des-Arg9-bradykinin and des …

Kinins are a family of peptides implicated in several pathophysiological events. Most of their
effects are likely mediated by the activation of two G‐protein‐coupled receptors: B1 and B2 …

Background and purpose: Bradykinin (BK) and B2 receptors have been implicated in the
pathophysiology of osteoarthritis (OA), and synovitis is one of its hallmarks. Here, the …

1 The mechanisms involved in bradykinin (BK)‐induced oedema in the rat paw as well as
the interactions between BK and several inflammatory mediators, have been investigated. 2 …

The kinins, particularly bradykinin (BK), are important mediators involved in both the
initiation and progression of an inflammatory response. The pro-inflammatory effects of …

In the present study we have investigated some of the mechanisms underlying B1 kinin
receptor-induced paw edema formation in rats that had been treated with LPS, paying …

The kinin B1 receptor (B1R) has attracted interest as a potential therapeutic target because
this inducible G protein-coupled receptor is involved in sustained inflammation and …

We demonstrated that rat kinin B 1 receptors displayed a ligand-independent constitutive
activity, assessed through inositol phosphate production in transiently or stably transfected …

To delineate ligand binding and functional characteristics of the human B 1 kinin receptor, a
stable clone of Chinese hamster ovary cells expressing a single class of binding sites for [3 …