Recent studies have suggested that the development of addictive behaviours shares
common features with traditional learning models. Synaptic plasticity, a possible substrate …

Experience-dependent changes in synaptic strength, or synaptic plasticity, may underlie
many learning processes. In the reward circuit for example, synaptic plasticity may serve as …

Addiction is caused, in part, by powerful and long-lasting memories of the drug experience.
Relapse caused by exposure to cues associated with the drug experience is a major clinical …

The clinical manifestations of drug addiction are the subject of medical literature and fiction
alike. In Novel with Cocaine, first published almost 80 years ago under a pseudonym and …

Drug addiction is a major public health issue worldwide. The persistence of drug craving
coupled with the known recruitment of learning and memory centers in the brain has led …

Opiates are among the most powerful analgesics and pain-relieving agents. However, they
are potentially extremely addictive thereby limiting their medical use, making them …

Considerable evidence suggests that neuroadaptations leading to addiction involve the
same glutamate-dependent cellular mechanisms that enable learning and memory. Long …

Although some aspects of drug addiction can occur relatively rapidly in response to acute
administration of a drug of abuse, most changes in brain function associated with addiction …

▪ Abstract One of the central questions in neurobiology is how experience modifies neural
function, and how changes in the nervous system permit an animal to adapt its behavior to a …

Studies of human addicts and behavioural studies in rodent models of addiction indicate that
key behavioural abnormalities associated with addiction are extremely long lived. So …