RP was a 26-year old man with a 9-year history of schizophrenia. 1 Refractory to previous
trials of antipsychotics, he was prescribed clozapine. After 3 weeks of 225 mg/d on …

Objective: Investigators have reported that weight gain attributed to clozapine is associated
with its clinical response. However, weight gain is a nonspecific physiological variable that …

OBJECTIVE: The authors' goal was to determine what effect dyslipidemia has on clozapine's
plasma distribution. METHOD:[3H] Clozapine plus cold clozapine (335 ng/ml) were …

Clozapine is known to be associated with higher risk of metabolic syndrome, including
dyslipidaemia, but the mechanisms of such a relationship are still under debate. The case …

The aim of this retrospective study is to determine whether lipid levels rise in neuroleptic-
resistant chronic schizophrenic patients during clozapine treatment and if this rise is …

The patient was a 48-year-old, 6 feet tall, 230 lb Caucasian male presenting to an indigent
care clinic. He was first hospitalized for depression three years before. Subsequently, he …

Increases in serum triglyceride (TG) levels are associated with clinical response to clozapine
treatment. Clozapine is the most efficacious therapy for treatment of refractory schizophrenia …

Abnormal lipid profiles have been reported in the central nervous system (CNS) in
individuals with schizophrenia, although the etiology of these changes remains to be …

Olanzapine and clozapine are chemically distinct from risperidone. 1 The former ones are
reported to be associated the most with weight gain, new-onset type 2 diabetes mellitus …

OBJECTIVE: This study was conducted to determine serum lipid level changes in patients
who received clozapine or haloperidol. METHOD: Medical records of 222 inpatients treated …