Drug-dependent neural plasticity related to drug addiction and schizophrenia can be
modeled in animals as behavioral sensitization, which is induced by repeated …

Repeated exposure to psychostimulant drugs such as cocaine or amphetamine can promote
drug-seeking and-taking behavior. In rodent addiction models, persistent changes in …

Chronic exposure to drugs of abuse induces countless modifications in brain physiology.
However, the neurobiological adaptations specifically associated with the transition to …

A compelling model of experience-dependent plasticity is the long-lasting sensitization to
the locomotor stimulatory effects of drugs of abuse. Adaptations in the nucleus accumbens …

Neuroplastic changes in the CNS are thought to be a fundamental component of learning
and memory. While pioneering studies in the hippocampus and cerebellum have detailed …

Plasticity of glutamatergic synapses is a fundamental mechanism through which experience
changes neural function to impact future behavior. In animal models of addiction …

Addiction is a behavioral disease, of which core components can be modeled in rodents.
Much evidence implicates drug-evoked synaptic plasticity in cocaine-evoked locomotor …

The neuroadaptation theory of addiction suggests that, similar to the development of most
memories, exposure to drugs of abuse induces adaptive molecular and cellular changes in …

The repeated use of drugs that directly or indirectly stimulate dopamine transmission carry
addiction liability and produce enduring pathological changes in the brain circuitry that …

Neuroadaptation in the nucleus accumbens (NAc), a central component of the mesolimbic
dopamine (DA) system, has been implicated in the development of cocaine-induced …