Nicotinic ligand binding studies have shown rather early that the cholinoceptive system is
affected in Alzheimer's disease (AD). Today, molecular histochemistry enables one to study …

Deficits of cortical nicotinic acetylcholine receptors (nAChRs) have been observed in
Alzheimer's disease (AD) by receptor binding assays. Little is known about the receptor …

The α4β2* nicotinic acetylcholine receptors (α4β2*-nAChR) are highly abundant in the
human brain. As neuromodulators they play an important role in cognitive functions such as …

β-Amyloid (1-42)(Aβ42), a major component of amyloid plaques, accumulates within
pyramidal neurons in the brains of individuals with Alzheimer's disease (AD) and Down …

Patients with dementia with Lewy bodies (DLB) commonly experience psychotic symptoms,
most notably visual hallucinations. Previously, it has been shown that visual hallucinations …

We compared the intact α7 nicotinic acetylcholine receptor (α7nAChR) protein levels in the
peripheral blood leukocytes in 15 Alzheimer's disease (AD) patients and 13 normal elderly …

The brain systems mostly affected by Alzheimer's disease (AD) are listed in Table 1 (Rossor
et al., 1982; Bird et al., 1983; Davies, 1979). They include either neuronal populations which …

Antibodies raised against human α2-6 and β2-4 nicotinic receptor subunits were utilized to
fractionate 3H-epibatidine binding in human temporal cortex and striatum. The predominant …

Cholinergic deficit associated with loss of nicotinic acetylcholine receptors (nAChRs) has
been described in Alzheimer's disease (AD) by receptor binding assays, positron emission …