Disease severity and the effect of fluticasone propionate on chronic obstructive pulmonary disease exacerbations

PW Jones, LR Willits, PS Burge… - European Respiratory …, 2003 - Eur Respiratory Soc
Exacerbations of chronic obstructive pulmonary disease (COPD) are associated with worse
health and increased healthcare utilisation. The Inhaled Steroids in Obstructive Lung …

Effect of discontinuation of inhaled corticosteroids in patients with chronic obstructive pulmonary disease: the COPE study

P van der Valk, E Monninkhof… - American journal of …, 2002 - atsjournals.org
The aim of this double-blind single center study (the COPE study) was to investigate the
effect of discontinuation of the inhaled corticosteroid fluticasone propionate (FP) on …

Impact of preventing exacerbations on deterioration of health status in COPD

S Spencer, PMA Calverley, PS Burge… - European respiratory …, 2004 - Eur Respiratory Soc
Exacerbations of chronic obstuctive pulmonary disease (COPD) are associated with worse
health status. The Inhaled Steroids in Obstructive Lung Disease in Europe (ISOLDE) study …

[HTML][HTML] Effect of budesonide/formoterol pMDI on COPD exacerbations: a double-blind, randomized study

A Sharafkhaneh, JG Southard, M Goldman… - Respiratory …, 2012 - Elsevier
BACKGROUND: Treatment with an inhaled corticosteroid (ICS) and long-acting
bronchodilator is recommended for severe/very severe chronic obstructive pulmonary …

Effect of fluticasone furoate and vilanterol on exacerbations of chronic obstructive pulmonary disease in patients with moderate airflow obstruction

FJ Martinez, J Vestbo, JA Anderson… - American journal of …, 2017 - atsjournals.org
Rationale: Inhaled corticosteroids have been shown to decrease exacerbations in patients
with moderate to severe chronic obstructive pulmonary disease (COPD). Their effects in …

Multicentre randomised placebo-controlled trial of inhaled fluticasone propionate in patients with chronic obstructive pulmonary disease

PL Paggiaro, R Dahle, I Bakran, L Frith, K Hollingworth… - The Lancet, 1998 - thelancet.com
Background The efficacy of inhaled corticosteroids in the treatment of chronic obstructive
pulmonary disease (COPD) remains controversial because of a lack of placebo-controlled …

[HTML][HTML] Effect of fluticasone propionate/salmeterol (250/50 μg) or salmeterol (50 μg) on COPD exacerbations

GT Ferguson, A Anzueto, R Fei, A Emmett, K Knobil… - Respiratory …, 2008 - Elsevier
OBJECTIVES: COPD exacerbations are associated with significant morbidity and mortality.
This randomized, double-blind, parallel-group, multicenter study evaluated the effect of …

Withdrawal of fluticasone propionate from combined salmeterol/fluticasone treatment in patients with COPD causes immediate and sustained disease deterioration: a …

EFM Wouters, DS Postma, B Fokkens, WCJ Hop… - Thorax, 2005 - thorax.bmj.com
Background: Guidelines recommend inhaled corticosteroids (ICS) as maintenance treatment
for patients with chronic obstructive pulmonary disease (COPD) with a post-bronchodilator …

[HTML][HTML] Inhaled drugs to reduce exacerbations in patients with chronic obstructive pulmonary disease: a network meta-analysis

MA Puhan, LM Bachmann, J Kleijnen, G Ter Riet… - BMC medicine, 2009 - Springer
Background Most patients with chronic obstructive pulmonary disease (COPD) receive
inhaled long-acting bronchodilators and inhaled corticosteroids. Conventional meta …

Randomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: the ISOLDE …

PS Burge, PMA Calverley, PW Jones, S Spencer… - Bmj, 2000 - bmj.com
Objectives: To determine the effect of long term inhaled corticosteroids on lung function,
exacerbations, and health status in patients with moderate to severe chronic obstructive …