AIM: To investigate whether there is a significant relationship between an increased
frequency of exacerbations and the rate of forced expiratory volume in 1s (FEV1) decline in …

The aim of this double-blind single center study (the COPE study) was to investigate the
effect of discontinuation of the inhaled corticosteroid fluticasone propionate (FP) on …

Prevention and treatment of COPD exacerbations are recognized as key goals in disease
management. This randomized, double-blind, parallel-group, multicenter study evaluated …

Background Exacerbations of chronic obstructive pulmonary disease (COPD) are
associated with loss of lung function and poor outcomes for patients. However, there are …

Background The natural history and time course of the onset of exacerbation events of
chronic obstructive pulmonary disease (COPD) is incompletely understood. Methods A …

The current study aimed to assess the impact on patient health status during an acute
exacerbation of chronic obstructive pulmonary disease (AECOPD). A total of 421 COPD …

This study examined health status decline in patients with chronic obstructive pulmonary
disease (COPD). Data are from the Inhaled Steroids in Obstructive Lung Disease (ISOLDE) …

Background Patients with chronic obstructive pulmonary disease (COPD) can be
categorized as having frequent (FE) or infrequent (IE) exacerbations depending on whether …

Personalised medicine aims to tailor medical decisions to the individual patient. A possible
approach is to stratify patients according to the risk of adverse outcomes such as …

Background: A study was undertaken to evaluate exacerbations and their impact on the
health related quality of life (HRQL) of patients with chronic obstructive pulmonary disease …