Background: Measurement of plasma total homocysteine has become common as new
methods have been introduced. A wide range of disorders are associated with increased …

This review will primarily address methodological aspects of homocysteine measurement,
highlighting changes since the subject was comprehensively reviewed in 1993, and will …

Total homocysteine is defined as the sum of all homocysteine species in plasma/serum,
including free and protein-bound forms. In the present review, we compare and evaluate …

Plasma total homocysteine (tHcy) determination is used in the diagnosis of homocystinuria,
in cobalamin and folate deficiency and in cardiovascular risk assessment. However …

Background: Information on interlaboratory variation and especially on methodological
differences for plasma total homocysteine is lacking. Methods: We studied 14 laboratories …

It is now widely accepted that increased total plasma homocysteine (tHcy) is a risk factor for
cardiovascular disease. Hyperhomocysteinemia can be caused by impaired enzyme …

Background: Total homocysteine (tHcy) has emerged as an important independent risk
factor for cardiovascular disease. Analytical methods are needed to accommodate the high …

Moderate hyperhomocysteinemia (HHCY) is a risk factor for cardiovascular (CVD) and
neurodegenerative diseases, osteoporotic fractures and complications during pregnancy …

High-performance liquid chromatography with fluorescence detection has been utilized for
the rapid determination of total homocysteine, cysteine, and cysteinylglycine in human …

Homocysteine exists in human plasma as various (mixed) disulfides. Most plasma
homocysteine (about 70%) is protein bound, probably via a disulfide bond to albumin …