Background Exacerbations affect morbidity in chronic obstructive pulmonary disease
(COPD). We sought to evaluate the association between exacerbation frequency and …

Background COPD exacerbations are responsible for the morbidity and mortality of this
disease. The relationship between exacerbations and patient-related clinical outcomes is …

Background COPD exacerbations are associated with accelerated lung function decline, but
whether they are causal is unknown. We evaluated the effect of a single exacerbation on …

Background Studies have shown that chronic obstructive pulmonary disease (COPD)
exacerbation events are related to future events; however, previous literature typically …

The epidemiology of exacerbations of chronic obstructive pulmonary disease (COPD) is
reviewed with particular reference to the definition, frequency, time course, natural history …

Background Pneumonia may be a major contributor to hospitalizations for chronic
obstructive pulmonary disease (COPD) exacerbation and influence their outcomes. Methods …

Introduction Severe exacerbations are the leading cause of fatal events in chronic
obstructive pulmonary disease (COPD). The new Global Initiative for Chronic Obstructive …

Severe chronic obstructive pulmonary disease (COPD) exacerbations requiring
hospitalization are a major cause of morbidity and mortality. Recognition of the importance …

Background Differences in previous exacerbation history may influence prognosis of chronic
obstructive pulmonary disease (COPD). We hypothesized that prognosis differs between …

Introduction Chronic obstructive pulmonary disease (COPD) exacerbations are associated
with systemic consequences. Data from a 4-year trial (Understanding Potential Long-term …