Drug-dependent neural plasticity related to drug addiction and schizophrenia can be
modeled in animals as behavioral sensitization, which is induced by repeated …

A single exposure to drugs of abuse produces an NMDA receptor (NMDAR)-dependent long-
term potentiation (LTP) of AMPA receptor (AMPAR) currents in DA neurons; however, the …

Chronic use of addictive drugs produces enduring neuroadaptations in the corticostriatal
glutamatergic brain circuitry. The nucleus accumbens (NAc), which integrates cortical …

Drug addiction is characterized by compulsive drug-seeking and drug-taking behavior and
by a high rate of relapse even after long periods of abstinence. Although the …

Abstract Trafficking of α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionate (AMPA)
receptors is an important determinant of synaptic strength. Our prior work suggests that D1 …

Addiction is characterized as a chronic relapsing disorder whereby addicted individuals
persistently engage in drug seeking and use despite profound negative consequences. The …

Nucleus accumbens (NAc) neurons are excited primarily by AMPA-type glutamate receptors
(AMPAR). This is required for cocaine seeking in animal models of cocaine addiction …

Exposure to addictive drugs causes changes in synaptic function within the striatal complex,
which can either mimic or interfere with the induction of synaptic plasticity. These synaptic …

This review focuses on cocaine-induced postsynaptic plasticity in the nucleus accumbens
(NAc) involving changes in AMPA receptor (AMPAR) transmission. First, fundamental …

Repeated administrations of addictive drugs produce long-lasting changes in brain and
behavior. However, drug-induced neurobehavioral plasticity is not a mere function of the …